HDAC1
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [ISO]
- cellular response to oxidative stress [ISO]
- chromatin modification [TAS]
- circadian regulation of gene expression [IDA]
- circadian rhythm [IDA]
- embryonic digit morphogenesis [IGI]
- endoderm development [IDA, IMP]
- epidermal cell differentiation [IGI]
- eyelid development in camera-type eye [IGI]
- fungiform papilla formation [IGI]
- hair follicle placode formation [IGI]
- hippocampus development [IGI]
- histone H3 deacetylation [IDA, ISO]
- histone H4 deacetylation [IDA, ISO]
- histone deacetylation [ISO]
- negative regulation by host of viral transcription [ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IGI]
- negative regulation of androgen receptor signaling pathway [ISO]
- negative regulation of apoptotic process [IGI]
- negative regulation of canonical Wnt signaling pathway [IGI]
- negative regulation of cell proliferation [ISO]
- negative regulation of insulin secretion [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [IGI]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of peptidyl-lysine acetylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- neuron differentiation [IGI]
- odontogenesis of dentin-containing tooth [IGI]
- positive regulation of cell proliferation [IGI, ISO]
- positive regulation of chemokine (C-X-C motif) ligand 2 production [ISO]
- positive regulation of interleukin-1 production [ISO]
- positive regulation of oligodendrocyte differentiation [IGI, ISO]
- positive regulation of receptor biosynthetic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- positive regulation of type B pancreatic cell apoptotic process [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- protein deacetylation [ISO]
- response to amphetamine [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- Krueppel-associated box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II repressing transcription factor binding [IPI, ISO]
- RNA polymerase II transcription corepressor activity [ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA, ISO]
- core promoter binding [IDA, ISO]
- deacetylase activity [IDA]
- enzyme binding [ISO]
- histone deacetylase activity [IDA, ISO]
- histone deacetylase binding [ISO]
- nucleosomal DNA binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein deacetylase activity [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription corepressor activity [IDA]
- transcription factor binding [ISO, TAS]
- transcription regulatory region DNA binding [ISO]
- transcription regulatory region sequence-specific DNA binding [IDA]
- DNA binding [IDA]
- Krueppel-associated box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II repressing transcription factor binding [IPI, ISO]
- RNA polymerase II transcription corepressor activity [ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA, ISO]
- core promoter binding [IDA, ISO]
- deacetylase activity [IDA]
- enzyme binding [ISO]
- histone deacetylase activity [IDA, ISO]
- histone deacetylase binding [ISO]
- nucleosomal DNA binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein deacetylase activity [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription corepressor activity [IDA]
- transcription factor binding [ISO, TAS]
- transcription regulatory region DNA binding [ISO]
- transcription regulatory region sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
- NuRD complex [IDA, IPI, ISO]
- Sin3 complex [ISO]
- chromatin [ISO]
- cytoplasm [TAS]
- cytosol [ISO]
- heterochromatin [IDA]
- histone deacetylase complex [IPI, TAS]
- neuron projection [ISO]
- neuronal cell body [IDA]
- nuclear chromatin [IDA, ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- protein complex [IDA, ISO]
- transcription factor complex [IDA, IPI]
- transcriptional repressor complex [IPI]
UBTF
Gene Ontology Biological Process
Gene Ontology Molecular Function
Biochemical Activity (Deacetylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Acetylation of UBF changes during the cell cycle and regulates the interaction of UBF with RNA polymerase I.
The upstream binding factor UBF, an activator of RNA polymerase I transcription, is posttranslationally modified by phosphorylation and acetylation. We found that in NIH3T3 cells, UBF is acetylated in S-phase but not in G1-phase. To assess the role of acetylation in regulation of UBF activity, we have established an NIH3T3 cell line that inducibly overexpresses HDAC1. Both in vivo and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| UBTF HDAC1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID