BAIT
MYSM1
2A-DUB, 2ADUB, RP4-592A1.1
Myb-like, SWIRM and MPN domains 1
GO Process (3)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HNRNPH1
HNRPH, HNRPH1, hnRNPH
heterogeneous nuclear ribonucleoprotein H1 (H)
GO Process (5)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation.
Deciphering the epigenetic "code" remains a central issue in transcriptional regulation. Here, we report the identification of a JAMM/MPN(+) domain-containing histone H2A deubiquitinase (2A-DUB, or KIAA1915/MYSM1) specific for monoubiquitinated H2A (uH2A) that has permitted delineation of a strategy for specific regulatory pathways of gene activation. 2A-DUB regulates transcription by coordinating histone acetylation and deubiquitination, and destabilizing the association of linker ... [more]
Mol. Cell Aug. 17, 2007; 27(4);609-21 [Pubmed: 17707232]
Throughput
- Low Throughput
Curated By
- BioGRID