RAD9
Gene Ontology Biological Process
Gene Ontology Molecular Function
POL30
Gene Ontology Biological Process
- chromatin silencing at silent mating-type cassette [IGI, IMP]
- chromatin silencing at telomere [IMP]
- error-free translesion synthesis [IGI]
- establishment of mitotic sister chromatid cohesion [IGI]
- lagging strand elongation [IDA, IPI]
- leading strand elongation [IDA]
- maintenance of DNA trinucleotide repeats [IGI, IMP]
- meiotic mismatch repair [IGI, IMP]
- mismatch repair [IGI, IMP, IPI]
- mitotic cell cycle [IGI]
- mitotic sister chromatid cohesion [IGI, IPI]
- nucleotide-excision repair [IMP]
- positive regulation of exodeoxyribonuclease activity [IDA]
- positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands [IDA]
- postreplication repair [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
The Role of Replication Bypass Pathways in Dicentric Chromosome Formation in Budding Yeast.
Gross chromosomal rearrangements (GCRs) are large scale changes to chromosome structure, and can lead to human disease. We previously showed in Saccharomyces cerevisiae, that nearby inverted repeat sequences (~20 to 200bp of homology, separated by ~1-5kb) frequently fuse to form unstable dicentric and acentric chromosomes. Here we analyzed inverted repeat fusion in mutants of three sets of genes. First, we ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: chromosome segregation (APO:0000208)
- phenotype: mutation frequency (APO:0000198)
Additional Notes
- double mutants show increased mixed colony formation indicative of increased mutation during DNA replication
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
RAD9 POL30 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -11.7377 | BioGRID | 213789 | |
POL30 RAD9 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 162934 |
Curated By
- BioGRID