BAIT

REB1

SPBC660.01c, SPBC1198.11c
RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1
Schizosaccharomyces pombe (972h)
PREY

WEE1

SPCC18B5.03
M phase inhibitor protein kinase Wee1
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

The fission yeast rDNA-binding protein Reb1 regulates G1 phase under nutritional stress.

Rodriguez-Sanchez L, Rodriguez-Lopez M, Garcia Z, Tenorio-Gomez M, Schvartzman JB, Krimer DB, Hernandez P

Yeast Reb1 and its mammalian ortholog TTF1 are conserved Myb-type DNA-binding proteins that bind to specific sites near the 3'-end of rRNA genes (rDNA). Here, they participate in the termination of transcription driven by RNA polymerase I and block DNA replication forks approaching in the opposite direction. We found that Schizosaccharomyces pombe Reb1 also upregulates transcription of the ste9(+) gene ... [more]

J. Cell. Sci. Nov. 30, 2010; 0(0); [Pubmed: 21118960]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)
  • phenotype: heat sensitivity (APO:0000147)

Additional Notes

  • reb1 wee1-50 double mutant

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
REB1 WEE1
Phenotypic Enhancement
Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
479669

Curated By

  • BioGRID