REB1
Gene Ontology Biological Process
- cis-acting DNA replication termination [IDA]
- positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation [IMP]
- replication fork arrest [IMP]
- replication fork arrest at rDNA repeats [IMP]
- termination of RNA polymerase I transcription [IMP]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
CDC10
Gene Ontology Biological Process
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription involved in G1/S transition of mitotic cell cycle [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- rRNA transcription [IDA]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IMP]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The fission yeast rDNA-binding protein Reb1 regulates G1 phase under nutritional stress.
Yeast Reb1 and its mammalian ortholog TTF1 are conserved Myb-type DNA-binding proteins that bind to specific sites near the 3'-end of rRNA genes (rDNA). Here, they participate in the termination of transcription driven by RNA polymerase I and block DNA replication forks approaching in the opposite direction. We found that Schizosaccharomyces pombe Reb1 also upregulates transcription of the ste9(+) gene ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
- phenotype: heat sensitivity (APO:0000147)
Additional Notes
- reb1 cdc10-129 double mutant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDC10 REB1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -5.1754 | BioGRID | 769813 | |
| REB1 CDC10 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 479671 |
Curated By
- BioGRID