BAIT
CLP1
flp1, SPAC1782.09c
Cdc14-related protein phosphatase Clp1/Flp1
GO Process (13)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IMP]
- chromosome passenger complex localization to spindle midzone [IMP]
- cytokinesis after mitosis checkpoint [IMP]
- cytokinesis checkpoint [IGI]
- mitotic actomyosin contractile ring maintenance [IGI, IMP]
- negative regulation of G2/M transition of mitotic cell cycle [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IGI]
- negative regulation of protein kinase activity [IMP]
- positive regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation [IMP]
- positive regulation of septation initiation signaling [IGI]
- regulation of exit from mitosis [IMP]
- regulation of mitotic sister chromatid segregation [IMP]
- response to mitotic cell cycle spindle assembly checkpoint signaling [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
FKH2
SPBC16G5.15c
forkhead transcription factor Fkh2
GO Process (8)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- induction of conjugation with cellular fusion [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- regulation of meiosis [IMP]
- regulation of mitotic cell cycle [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IMP]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Regulation of cell cycle-specific gene expression in fission yeast by the Cdc14p-like phosphatase Clp1p.
Regulated gene expression makes an important contribution to cell cycle control mechanisms. In fission yeast, a group of genes is coordinately expressed during a late stage of the cell cycle (M phase and cytokinesis) that is controlled by common cis-acting promoter motifs named pombe cell cycle boxes (PCBs), which are bound by a trans-acting transcription factor complex, PCB binding factor ... [more]
J. Cell. Sci. Dec. 15, 2010; 123(0);4374-81 [Pubmed: 21098641]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID