BAIT
ABC2
SPAC3F10.11c
glutathione S-conjugate-exporting ATPase Abc2
GO Process (3)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
HMT1
SPCC74.08c, SPCC737.09c
ATP-binding cassette-type vacuolar membrane transporter Hmt1
GO Process (9)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- cadmium ion import into vacuole [IMP]
- cadmium ion transmembrane transport [IMP]
- cellular response to cadmium ion [IGI, IMP]
- detoxification of cadmium ion [IMP]
- glutathione transmembrane import into vacuole [IMP]
- phytochelatin 2 import into vacuole [IMP]
- phytochelatin 3 import into vacuole [IMP]
- phytochelatin 4 import into vacuole [IMP]
- phytochelatin import into vacuole [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Schizosaccharomyces pombe Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance.
Phytochelatins mediate tolerance to heavy metals in plants and some fungi by sequestering phytochelatin-metal complexes into vacuoles. To date, only Schizosaccharomyces pombe Hmt1 has been described as a phytochelatin transporter and attempts to identify orthologous phytochelatin transporters in plants and other organisms have failed. Furthermore, recent data indicate that the hmt1 mutant accumulates significant phytochelatin levels in vacuoles, suggesting that ... [more]
J. Biol. Chem. Oct. 11, 2010; 0(0); [Pubmed: 20937798]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
- phenotype: metal resistance (APO:0000090)
Additional Notes
- An abc2 hmt1 mutant shows increased sensitivity to cadmium.
Curated By
- BioGRID