A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

Aggregation of Î±-Synuclein in S. cerevisiae is Associated with Defects in Endosomal Trafficking and Phospholipid Biosynthesis.

Soper JH, Kehm V, Burd CG, Bankaitis VA, Lee VM

Parkinson's disease is the most common neurodegenerative movement disorder. Î±-Synuclein is a small synaptic protein that has been linked to familial Parkinson's disease (PD) and is also the primary component of Lewy bodies, the hallmark neuropathology found in the brain of sporadic and familial PD patients. The function of Î±-synuclein is currently unknown, although it has been implicated in the ... [more]

J. Mol. Neurosci. Oct. 02, 2010; 0(0); [Pubmed: 20890676]

Throughput

Low Throughput

Ontology Terms

phenotype: vegetative growth (APO:0000106)

Additional Notes

expression of Syn-EGFP and deletion of the hit protein causes growth defects in S cerevisiae

Curated By

BioGRID

Interaction Summary

SNCAIP

Gene Ontology Biological Process

Gene Ontology Molecular Function

identical protein binding [IPI]protein binding [IPI]ubiquitin protein ligase binding [IPI]

Gene Ontology Cellular Component

RGP1