PRMT5
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- cell proliferation [TAS]
- circadian regulation of gene expression [ISS]
- endothelial cell activation [IMP]
- gene expression [TAS]
- histone H4-R3 methylation [ISS, NAS]
- ncRNA metabolic process [TAS]
- peptidyl-arginine N-methylation [IDA]
- peptidyl-arginine methylation [IMP]
- peptidyl-arginine methylation, to symmetrical-dimethyl arginine [IMP]
- regulation of mitosis [TAS]
- regulation of transcription, DNA-templated [IBA]
- spliceosomal snRNP assembly [IMP, TAS]
Gene Ontology Molecular Function
SIN3A
Gene Ontology Biological Process
- activation of innate immune response [IMP]
- blood coagulation [TAS]
- cellular lipid metabolic process [TAS]
- histone deacetylation [IBA]
- negative regulation of circadian rhythm [ISS]
- negative regulation of histone H3-K27 acetylation [IMP]
- negative regulation of protein localization to nucleus [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription regulatory region DNA binding [IMP]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of chromatin silencing [IMP]
- positive regulation of defense response to virus by host [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein deacetylation [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Sin3 complex [IDA, NAS]
- cytoplasm [IDA]
- intercellular bridge [IDA]
- nucleoplasm [IDA, TAS]
- nucleus [IDA, ISS]
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad.
The role of hSWI/SNF complexes in transcriptional activation is well characterized; however, little is known about their function in transcriptional repression. We have previously shown that subunits of the mSin3A/histone deacetylase 2 (HDAC2) corepressor complex copurify with hSWI/SNF complexes. Here we show that the type II arginine-specific methyltransferase PRMT5, which is involved in cyclin E repression, can be found in ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PRMT5 SIN3A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
PRMT5 SIN3A | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | - | BioGRID | 3430553 | |
SIN3A PRMT5 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID