BAIT
EYA2
Eab1, RP23-138C10.1
eyes absent 2 homolog (Drosophila)
GO Process (6)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
SHARPIN
0610041B22Rik, AW121341, RBCKL1, SIPL1, cpdm
SHANK-associated RH domain interacting protein
GO Process (10)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- apoptotic nuclear changes [IMP]
- epidermis development [IMP]
- keratinization [IMP]
- mitochondrion organization [IMP]
- negative regulation of inflammatory response [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP, ISO]
- protein homooligomerization [ISO]
- protein linear polyubiquitination [ISO]
- regulation of CD40 signaling pathway [ISO]
- regulation of tumor necrosis factor-mediated signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development.
The eyes absent 1 protein (Eya1) plays an essential role in the development of various organs in both invertebrates and vertebrates. Mutations in the human EYA1 gene are linked to BOR (branchio-oto-renal) syndrome, characterized by kidney defects, hearing loss, and branchial arch anomalies. For a better understanding of Eya1's function, we have set out to identify new Eya1-interacting proteins. Here ... [more]
Mol. Cell. Biol. Dec. 01, 2010; 30(24);5764-75 [Pubmed: 20956555]
Throughput
- Low Throughput
Curated By
- BioGRID