PIF1
Gene Ontology Biological Process
- DNA recombination [IMP]
- DNA strand renaturation [IDA]
- G-quadruplex DNA unwinding [IMP]
- chromosome organization [IMP]
- double-strand break repair via break-induced replication [IMP]
- mitochondrial genome maintenance [IMP]
- negative regulation of telomere maintenance via telomerase [IDA, IMP]
- telomere maintenance [IMP]
- telomere maintenance via recombination [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RAD27
Gene Ontology Biological Process
- DNA replication, removal of RNA primer [IDA]
- base-excision repair, base-free sugar-phosphate removal [IGI, IMP]
- double-strand break repair via nonhomologous end joining [IDA]
- gene conversion at mating-type locus, DNA repair synthesis [IMP]
- maintenance of DNA trinucleotide repeats [IGI, IMP]
- replicative cell aging [IMP]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Components of the secondary pathway stimulate the primary pathway of eukaryotic Okazaki fragment processing.
Reconstitution of eukaryotic Okazaki fragment processing implicates both one- and two-nuclease pathways for processing flap intermediates. In most cases, FEN1 (flap endonuclease 1) is able to efficiently cleave short flaps as they form. However, flaps escaping cleavage bind replication protein A (RPA) inhibiting FEN1. The flaps must then be cleaved by Dna2 nuclease/helicase before FEN1 can act. Pif1 helicase aids ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
RAD27 PIF1 | Dosage Growth Defect Dosage Growth Defect A genetic interaction is inferred when over expression or increased dosage of one gene causes a growth defect in a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 447971 | |
RAD27 PIF1 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | High | - | BioGRID | 457571 |
Curated By
- BioGRID