HDAC1
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [IDA]
- Notch signaling pathway [TAS]
- blood coagulation [TAS]
- chromatin modification [TAS]
- chromatin remodeling [IC]
- circadian regulation of gene expression [ISS]
- embryonic digit morphogenesis [ISS]
- epidermal cell differentiation [ISS]
- eyelid development in camera-type eye [ISS]
- fungiform papilla formation [ISS]
- gene expression [TAS]
- hair follicle placode formation [ISS]
- histone H3 deacetylation [IDA]
- histone H4 deacetylation [IDA]
- histone deacetylation [IMP]
- mitotic cell cycle [TAS]
- negative regulation by host of viral transcription [IMP]
- negative regulation of androgen receptor signaling pathway [IDA]
- negative regulation of apoptotic process [ISS]
- negative regulation of cell cycle [TAS]
- negative regulation of myotube differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP, TAS]
- negative regulation of transcription, DNA-templated [IMP, ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- odontogenesis of dentin-containing tooth [ISS]
- positive regulation of cell proliferation [IMP]
- positive regulation of receptor biosynthetic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein deacetylation [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- RNA polymerase II transcription corepressor activity [IDA]
- activating transcription factor binding [IPI]
- core promoter binding [IDA]
- deacetylase activity [ISS]
- enzyme binding [IPI]
- histone deacetylase activity [IDA, IMP, TAS]
- histone deacetylase binding [IPI]
- nucleosomal DNA binding [IDA]
- protein binding [IPI]
- protein deacetylase activity [IDA, IMP]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI, TAS]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- RNA polymerase II transcription corepressor activity [IDA]
- activating transcription factor binding [IPI]
- core promoter binding [IDA]
- deacetylase activity [ISS]
- enzyme binding [IPI]
- histone deacetylase activity [IDA, IMP, TAS]
- histone deacetylase binding [IPI]
- nucleosomal DNA binding [IDA]
- protein binding [IPI]
- protein deacetylase activity [IDA, IMP]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI, TAS]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [ISS]
Gene Ontology Cellular Component
CRYAB
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Sensitization of RPE cells by alphaB-crystallin siRNA to SAHA-induced stage 1 apoptosis through abolishing the association of alphaB-crystallin with HDAC1 in SC35 speckles.
To better understand the mechanism underlying the anti-apoptotic activity of alphaB-crystallin in RPE cells.Cells of the human retinal pigment epithelial line ARPE-19 were treated with a histone deacetylase inhibitor (HDACI), suberoylanilide hydroxamic acid (SAHA), with or without alphaB-crystallin siRNA. To examine the mechanism underlying the cell death induced in ARPE-19 cells, nuclear staining, flow cytometry, DNA electrophoresis, pulse field gel ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID