GHR
Gene Ontology Biological Process
- 2-oxoglutarate metabolic process [ISS]
- JAK-STAT cascade [ISS]
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- activation of JAK2 kinase activity [ISS]
- activation of MAPK activity [ISS]
- allantoin metabolic process [ISS]
- cellular response to hormone stimulus [IMP]
- citrate metabolic process [ISS]
- creatine metabolic process [ISS]
- creatinine metabolic process [ISS]
- fatty acid metabolic process [ISS]
- growth hormone receptor signaling pathway [IMP]
- insulin-like growth factor receptor signaling pathway [IMP]
- isoleucine metabolic process [ISS]
- multicellular organismal metabolic process [IMP]
- oxaloacetate metabolic process [ISS]
- positive regulation of multicellular organism growth [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISS]
- positive regulation of tyrosine phosphorylation of Stat5 protein [ISS]
- receptor internalization [IDA]
- regulation of multicellular organism growth [ISS]
- response to cycloheximide [IDA]
- response to estradiol [IDA]
- succinate metabolic process [ISS]
- taurine metabolic process [ISS]
- valine metabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DUSP7
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- inactivation of MAPK activity [IDA]
- innate immune response [TAS]
- negative regulation of MAP kinase activity [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine dephosphorylation [IDA]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytosol [IDA]
- nucleoplasm [TAS]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor.
Protein tyrosine phosphatases (PTPs) play key roles in switching off tyrosine phosphorylation cascades, such as initiated by cytokine receptors. We have used substrate-trapping mutants of a large set of PTPs to identify members of the PTP family that have substrate specificity for the phosphorylated human GH receptor (GHR) intracellular domain. Among 31 PTPs tested, T cell (TC)-PTP, PTP-beta, PTP1B, stomach ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID