ADRBK1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA, ISO]
- aging [IEP]
- cardiac muscle contraction [ISO]
- desensitization of G-protein coupled receptor protein signaling pathway [IC, IDA, IMP, ISO]
- follicle-stimulating hormone signaling pathway [IDA]
- heart development [ISO]
- negative regulation of G-protein coupled receptor protein signaling pathway [IDA]
- negative regulation of striated muscle contraction [ISO]
- negative regulation of the force of heart contraction by chemical signal [ISO]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of catecholamine secretion [IDA]
- protein phosphorylation [IDA, ISO]
- receptor internalization [ISO]
- regulation of the force of heart contraction [ISO]
- response to hydrogen peroxide [IEP]
- response to organic cyclic compound [IDA]
- response to oxidative stress [IDA]
- tachykinin receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HDAC5
Gene Ontology Biological Process
- B cell activation [TAS]
- B cell differentiation [TAS]
- Notch signaling pathway [TAS]
- cellular response to insulin stimulus [NAS]
- chromatin modification [TAS]
- chromatin organization [TAS]
- chromatin remodeling [TAS]
- chromatin silencing [TAS]
- histone deacetylation [IDA]
- inflammatory response [TAS]
- negative regulation of cell migration involved in sprouting angiogenesis [IMP]
- negative regulation of myotube differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [TAS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of gene expression, epigenetic [IMP]
- regulation of myotube differentiation [ISS]
- regulation of protein binding [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
G betagamma binds histone deacetylase 5 (HDAC5) and inhibits its transcriptional co-repression activity.
In a yeast two-hybrid screen designed to identify novel effectors of the G betagamma subunit of heterotrimeric G proteins, we found that G betagamma binds to histone deacetylase 5 (HDAC5), an enzyme involved in a pathway not previously recognized to be directly impacted by G proteins. Formation of the G beta1gamma2-HDAC5 complex in mammalian cells can be blocked by overexpression ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID