ADRBK1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA, ISO]
- aging [IEP]
- cardiac muscle contraction [ISO]
- desensitization of G-protein coupled receptor protein signaling pathway [IC, IDA, IMP, ISO]
- follicle-stimulating hormone signaling pathway [IDA]
- heart development [ISO]
- negative regulation of G-protein coupled receptor protein signaling pathway [IDA]
- negative regulation of striated muscle contraction [ISO]
- negative regulation of the force of heart contraction by chemical signal [ISO]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of catecholamine secretion [IDA]
- protein phosphorylation [IDA, ISO]
- receptor internalization [ISO]
- regulation of the force of heart contraction [ISO]
- response to hydrogen peroxide [IEP]
- response to organic cyclic compound [IDA]
- response to oxidative stress [IDA]
- tachykinin receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GNB1
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [TAS]
- GTP catabolic process [IDA, TAS]
- Ras protein signal transduction [TAS]
- adenylate cyclase-activating dopamine receptor signaling pathway [ISS]
- blood coagulation [TAS]
- cellular response to catecholamine stimulus [ISS]
- cellular response to glucagon stimulus [TAS]
- cellular response to prostaglandin E stimulus [ISS]
- energy reserve metabolic process [TAS]
- phototransduction, visible light [TAS]
- platelet activation [TAS]
- regulation of rhodopsin mediated signaling pathway [TAS]
- rhodopsin mediated signaling pathway [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
G betagamma binds histone deacetylase 5 (HDAC5) and inhibits its transcriptional co-repression activity.
In a yeast two-hybrid screen designed to identify novel effectors of the G betagamma subunit of heterotrimeric G proteins, we found that G betagamma binds to histone deacetylase 5 (HDAC5), an enzyme involved in a pathway not previously recognized to be directly impacted by G proteins. Formation of the G beta1gamma2-HDAC5 complex in mammalian cells can be blocked by overexpression ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID