CD220, HHF5
insulin receptor
GO Process (28)
GO Function (13)
GO Component (9)
Homo sapiens


Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.


C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor.

Arbet-Engels C, Tartare-Deckert S, Eckhart W

Increased expression of the insulin-like growth factor-I receptor (IGF-IR) protein-tyrosine kinase occurs in several kinds of cancer and induces neoplastic transformation in fibroblast cell lines. The transformed phenotype can be reversed by interfering with the function of the IGF-IR. The IGF-IR is required for transformation by a number of viral and cellular oncoproteins, including SV40 large T antigen, Ras, Raf, ... [more]

J. Biol. Chem. Feb. 26, 1999; 274(9);5422-8 [Pubmed: 10026153]


  • Low Throughput

Curated By

  • BioGRID