A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Schizosaccharomyces pombe Mms1 channels repair of perturbed replication into Rhp51 independent homologous recombination.

Vejrup-Hansen R, Mizuno K, Miyabe I, Fleck O, Holmberg C, Murray JM, Carr AM, Nielsen O

In both Schizosaccharomyces pombe and Saccharomyces cerevisiae, Mms22 and Mms1 form a complex with important functions in the response to DNA damage, loss of which leads to perturbations during replication. Furthermore, in S. cerevisiae, Mms1 has been suggested to function in concert with a Cullin-like protein, Rtt101/Cul8, a potential paralog of Cullin 4. We performed epistasis analysis between Î”mms1 and ... [more]

Unknown Dec. 21, 2010; 0(0); [Pubmed: 21183410]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)
phenotype: uv resistance (APO:0000085)

Curated By

BioGRID

Interaction Summary

MMS1

Gene Ontology Biological Process

Gene Ontology Cellular Component

RAD13