E3 ubiquitin ligase complex subunit Mms1 (predicted)
GO Process (3)
GO Function (0)
GO Component (3)
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


Schizosaccharomyces pombe Mms1 channels repair of perturbed replication into Rhp51 independent homologous recombination.

Vejrup-Hansen R, Mizuno K, Miyabe I, Fleck O, Holmberg C, Murray JM, Carr AM, Nielsen O

In both Schizosaccharomyces pombe and Saccharomyces cerevisiae, Mms22 and Mms1 form a complex with important functions in the response to DNA damage, loss of which leads to perturbations during replication. Furthermore, in S. cerevisiae, Mms1 has been suggested to function in concert with a Cullin-like protein, Rtt101/Cul8, a potential paralog of Cullin 4. We performed epistasis analysis between Δmms1 and ... [more]

Unknown Dec. 21, 2010; 0(0); [Pubmed: 21183410]


  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)
  • phenotype: resistance to chemicals (APO:0000087)

Additional Notes

  • Methyl Methanesulfonate (MMS) (CHEBI:25255 and PubChem CID:4156)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.


Curated By

  • BioGRID