PHO84
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PHO90
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Differential roles for the low-affinity phosphate transporters Pho87 and Pho90 in Saccharomyces cerevisiae.
When starved for phosphate (Pi), yeast cells activate the PHO-signaling pathway, wherein the Pho4 transcription factor mediates expression of genes involved in Pi-acquisition, such as PHO84, encoding the high-affinity H+/Pi-symporter. In contrast, transcription of PHO87 and PHO90, encoding the low-affinity H+/Pi-transport system, is independent of phosphate status. Here, we reveal that upon Pi-starvation, these low-affinity phosphate transporters are endocytosed and ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: utilization of phosphorus source (APO:0000125)
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- genetic complex
- triple mutants show a growth defect at in low phosphate media
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PHO90 PHO84 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.165 | BioGRID | 389345 | |
| PHO90 PHO84 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1374 | BioGRID | 2137966 | |
| PHO84 PHO90 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 258307 | |
| PHO90 PHO84 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 258314 | |
| PHO84 PHO90 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 422877 | |
| PHO84 PHO90 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 161499 |
Curated By
- BioGRID