MYO52
Gene Ontology Biological Process
- actin filament bundle organization [IMP]
- actin filament bundle retrograde transport [IMP]
- cellular protein localization [IMP]
- establishment or maintenance of cell polarity regulating cell shape [IMP]
- formin-nucleated actin cable assembly [IMP]
- mitotic cytokinesis [IMP]
- protein localization to cell tip [IMP]
- vesicle transport along actin filament [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SEC8
Gene Ontology Biological Process
Gene Ontology Molecular Function
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Actin cables and the exocyst form two independent morphogenesis pathways in the fission yeast.
Cell morphogenesis depends on polarized exocytosis. One widely held model posits that long-range transport and exocyst-dependent tethering of exocytic vesicles at the plasma membrane sequentially drive this process. Here, we describe that disruption of either actin-based long-range transport and microtubules or the exocyst did not abolish polarized growth in rod-shaped fission yeast cells. However, disruption of both actin cables and ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: cell shape (APO:0000051)
Additional Notes
- addition of a GFP tag to sec8 causes severe morphology defects in a for3 or myo52 background
- deletion and depletion of sec8 also causes aberrant morphology in a for3 or myo52 mutant background
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MYO52 SEC8 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 482902 | |
| SEC8 MYO52 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 736877 |
Curated By
- BioGRID