Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Actin cables and the exocyst form two independent morphogenesis pathways in the fission yeast.

Bendezu FO, Martin SG

Cell morphogenesis depends on polarized exocytosis. One widely held model posits that long-range transport and exocyst-dependent tethering of exocytic vesicles at the plasma membrane sequentially drive this process. Here, we describe that disruption of either actin-based long-range transport and microtubules or the exocyst did not abolish polarized growth in rod-shaped fission yeast cells. However, disruption of both actin cables and ... [more]

Unknown Dec. 09, 2010; 0(0); [Pubmed: 21148300]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: cell shape (APO:0000051)

Additional Notes

  • deletion of exo70 causes aberrant morphology in a for3 or myo52 mutant background

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
MYO52 EXO70
Synthetic Growth Defect
Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Low-BioGRID
736881
MYO52 EXO70
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
482904

Curated By

  • BioGRID