MIS4
Gene Ontology Biological Process
- attachment of mitotic spindle microtubules to kinetochore [IMP]
- cellular response to nitrogen starvation [IMP]
- cohesin localization to chromatin [IMP]
- mitotic sister chromatid cohesion [IGI, IMP]
- mitotic spindle organization [IMP]
- negative regulation of G0 to G1 transition [IMP]
- positive regulation of maintenance of mitotic sister chromatid cohesion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SWI6
Gene Ontology Biological Process
- cellular protein localization [IMP]
- chromatin remodeling [NAS]
- chromatin silencing at centromere [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- chromatin silencing at telomere [IMP]
- chromosome passenger complex localization to kinetochore [NAS]
- donor selection [IMP]
- gene conversion at mating-type locus [IMP]
- mating type switching [IMP]
- mitotic sister chromatid cohesion [IGI]
- negative regulation of reciprocal meiotic recombination [IMP]
- protein localization to chromosome, centromeric region [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
A role for cohesin in the formation of a heterochromatic domain at fission yeast subtelomeres.
Increasing evidence implicates cohesin in the control of gene expression. Here we report the first analysis of cohesin-dependent gene regulation in fission yeast. Global expression profiling of the cohesin loader mutant mis4-367 identified a small number of upregulated and downregulated genes located within subtelomeric domains (SD). These 20-40 kb regions between chromosome arm euchromatin and telomere-proximal heterochromatin are characterized by ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: protein/peptide accumulation (APO:0000149)
Additional Notes
- mutation of swi6 or rad21 abrogates the effect of mis4 mutation on subtelomeric DNA transcription
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MIS4 SWI6 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | - | BioGRID | 735425 |
Curated By
- BioGRID