TAF1B
Gene Ontology Biological Process
- RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript [IDA]
- gene expression [TAS]
- termination of RNA polymerase I transcription [TAS]
- transcription elongation from RNA polymerase I promoter [TAS]
- transcription from RNA polymerase I promoter [TAS]
- transcription initiation from RNA polymerase I promoter [TAS]
- transcription, DNA-templated [NAS]
Gene Ontology Molecular Function- RNA polymerase I CORE element sequence-specific DNA binding [IDA]
- RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity [IDA]
- TBP-class protein binding [TAS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- RNA polymerase I CORE element sequence-specific DNA binding [IDA]
- RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity [IDA]
- TBP-class protein binding [TAS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
Gene Ontology Cellular Component
PGR
Gene Ontology Biological Process
Gene Ontology Molecular Function- DNA binding [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- enzyme binding [IPI]
- protein binding [IPI]
- receptor binding [IPI]
- DNA binding [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- enzyme binding [IPI]
- protein binding [IPI]
- receptor binding [IPI]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
A novel estrogen receptor alpha-associated protein, template-activating factor Ibeta, inhibits acetylation and transactivation.
Estrogen receptor-alpha (ERalpha) functions as a ligand-activated transcription factor that alters expression of estrogen-responsive genes in target cells. Numerous regulatory proteins interact with ERalpha to influence estrogen-mediated transactivation. We have identified a novel coregulatory protein, template-activating factor-Ibeta (TAF-Ibeta), which binds to ERalpha in vitro when the receptor is not complexed with an estrogen response element. The central region of TAF-Ibeta ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID