SP3
Gene Ontology Biological Process
- B cell differentiation [IMP]
- T cell differentiation [IMP]
- definitive hemopoiesis [IGI]
- embryonic camera-type eye morphogenesis [IGI]
- embryonic placenta development [IGI]
- embryonic process involved in female pregnancy [IGI]
- embryonic skeletal system development [IGI]
- enucleate erythrocyte differentiation [IGI]
- erythrocyte differentiation [IMP]
- granulocyte differentiation [IMP]
- in utero embryonic development [IGI]
- liver development [IGI]
- lung development [IGI]
- megakaryocyte differentiation [IGI]
- monocyte differentiation [IMP]
- natural killer cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- ossification [IGI]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of transcription, DNA-templated [ISO, TAS]
- transcription from RNA polymerase II promoter [ISO]
- trophectodermal cell differentiation [IGI]
Gene Ontology Molecular Function- DNA binding [IDA, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- chromatin binding [IDA]
- core promoter proximal region sequence-specific DNA binding [IDA]
- double-stranded DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- DNA binding [IDA, ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA, ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- chromatin binding [IDA]
- core promoter proximal region sequence-specific DNA binding [IDA]
- double-stranded DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
Gene Ontology Cellular Component
HDAC2
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [ISO]
- cardiac muscle cell development [IMP]
- cellular response to hydrogen peroxide [ISO]
- chromatin modification [TAS]
- circadian regulation of gene expression [IDA]
- dendrite development [IMP]
- embryonic digit morphogenesis [IGI]
- epidermal cell differentiation [IGI]
- eyelid development in camera-type eye [IGI]
- fungiform papilla formation [IGI]
- hair follicle placode formation [IGI]
- hippocampus development [IGI]
- histone H3 deacetylation [IDA, ISO]
- histone H4 deacetylation [IDA]
- histone deacetylation [IGI, ISO, TAS]
- maintenance of chromatin silencing [ISO]
- negative regulation of DNA binding [ISO]
- negative regulation of apoptotic process [IGI]
- negative regulation of canonical Wnt signaling pathway [IGI]
- negative regulation of cardiac muscle cell proliferation [IMP]
- negative regulation of dendritic spine development [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [IGI]
- negative regulation of neuron projection development [IDA, ISO]
- negative regulation of peptidyl-lysine acetylation [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- neuron differentiation [IGI]
- odontogenesis of dentin-containing tooth [IGI]
- positive regulation of cell proliferation [IGI, ISO]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of interleukin-1 production [ISO]
- positive regulation of oligodendrocyte differentiation [IGI, ISO]
- positive regulation of proteolysis [ISO]
- positive regulation of receptor biosynthetic process [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- protein deacetylation [IDA]
- regulation of protein deacetylation [IGI]
- regulation of protein kinase B signaling [IMP]
- regulation of sarcomere organization [IMP]
Gene Ontology Molecular Function- Krueppel-associated box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- chromatin DNA binding [IDA]
- chromatin binding [IDA]
- core promoter binding [ISO]
- deacetylase activity [IDA]
- enzyme binding [IPI, ISO]
- heat shock protein binding [ISO]
- histone deacetylase activity [IDA, ISO, TAS]
- nucleosomal DNA binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [ISO, TAS]
- Krueppel-associated box domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- chromatin DNA binding [IDA]
- chromatin binding [IDA]
- core promoter binding [ISO]
- deacetylase activity [IDA]
- enzyme binding [IPI, ISO]
- heat shock protein binding [ISO]
- histone deacetylase activity [IDA, ISO, TAS]
- nucleosomal DNA binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [ISO, TAS]
Gene Ontology Cellular Component
- ESC/E(Z) complex [ISO]
- NuRD complex [ISO]
- Sin3 complex [ISO]
- chromatin [ISO]
- cytoplasm [ISO, TAS]
- heterochromatin [IDA]
- histone deacetylase complex [TAS]
- nuclear chromatin [IDA, ISO]
- nucleus [IDA, ISO]
- protein complex [ISO]
- replication fork [IDA]
- transcription factor complex [IPI]
- transcriptional repressor complex [IPI]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Association of the mSin3A-histone deacetylase 1/2 corepressor complex with the mouse steroidogenic acute regulatory protein gene.
Several factors have been identified in the transcriptional repression of the steroidogenic acute regulatory protein (StAR) gene promoter; yet, no associating corepressor complexes have been characterized for the mouse promoter in MA-10 mouse Leydig tumor cells. We now report that Sp3, CAGA element binding proteins, and a corepressor complex consisting of mSin3A, histone deacetylase (HDAC)1, and HDAC2 associates with a ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HDAC2 SP3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID