JDP2
Gene Ontology Biological Process
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
Gene Ontology Cellular Component
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
HDAC3
Gene Ontology Biological Process
- cellular response to fluid shear stress [ISO]
- chromatin modification [TAS]
- circadian regulation of gene expression [IGI]
- histone deacetylation [IGI, IMP, ISO]
- negative regulation of JNK cascade [ISO]
- negative regulation of cardiac muscle cell differentiation [IMP]
- negative regulation of interleukin-1 production [ISO]
- negative regulation of protein export from nucleus [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of tumor necrosis factor production [ISO]
- positive regulation of TOR signaling [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of type B pancreatic cell apoptotic process [ISO]
- protein deacetylation [IDA, ISO]
- regulation of mitotic cell cycle [IDA]
- regulation of multicellular organism growth [IGI]
- regulation of protein stability [ISO]
- spindle assembly [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- GTPase binding [ISO]
- chromatin DNA binding [IDA]
- chromatin binding [IDA, ISO]
- cyclin binding [ISO]
- enzyme binding [ISO]
- histone deacetylase activity [ISO, TAS]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IDA, ISO, TAS]
- DNA binding [IDA]
- GTPase binding [ISO]
- chromatin DNA binding [IDA]
- chromatin binding [IDA, ISO]
- cyclin binding [ISO]
- enzyme binding [ISO]
- histone deacetylase activity [ISO, TAS]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IDA, ISO, TAS]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
JDP2, a repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells.
Up-regulation of the c-jun gene is a critical event in the retinoic acid (RA)-mediated differentiation of embryonal carcinoma F9 cells. Activating transcription factor 2 (ATF-2) and p300 cooperate in the activation of transcription of the c-jun gene during the differentiation of F9 cells. We show here that the overexpression of Jun dimerization protein 2 (JDP2), a repressor of AP-1, inhibits ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| JDP2 HDAC3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| JDP2 HDAC3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID