BAIT
AGRN
Agrin, nmf380, RP23-139J18.2
agrin
GO Process (21)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- neuromuscular junction development [IGI]
- neurotransmitter receptor metabolic process [IDA]
- plasma membrane organization [IMP]
- positive regulation of Rho GTPase activity [ISO]
- positive regulation of filopodium assembly [ISO]
- positive regulation of neuron apoptotic process [IMP]
- positive regulation of protein binding [IDA]
- positive regulation of protein geranylgeranylation [IMP]
- positive regulation of protein phosphorylation [IDA, ISO]
- positive regulation of synaptic growth at neuromuscular junction [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- protein heterotetramerization [ISO]
- receptor clustering [IDA, IGI, IMP, ISO]
- regulation of Rac GTPase activity [IDA]
- regulation of axon guidance [ISO]
- regulation of microtubule cytoskeleton organization [ISO]
- regulation of protein phosphorylation [ISO]
- regulation of receptor activity [IDA]
- regulation of synaptic growth at neuromuscular junction [IMP]
- synapse assembly [ISO]
- synaptic transmission [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PAK1IP1
MAK11, PIP1, WDR84, bA421M1.5, hPIP1, RP11-421M1.5
PAK1 interacting protein 1
GO Process (0)
GO Function (0)
GO Component (2)
Gene Ontology Cellular Component
Homo sapiens
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1.
An important aspect of synapse development is the clustering of neurotransmitter receptors in the postsynaptic membrane. Although MuSK is required for acetylcholine receptor (AChR) clustering at the neuromuscular junction (NMJ), the underlying molecular mechanisms remain unclear. We report here that in muscle cells, MuSK interacts with Dishevelled (Dvl), a signaling molecule important for planar cell polarity. Disruption of the MuSK-Dvl ... [more]
Neuron Aug. 01, 2002; 35(3);489-505 [Pubmed: 12165471]
Throughput
- Low Throughput
Ontology Terms
- phenotype: abnormal neuromuscular synapse morphology (MP:0001053)
Additional Notes
- expression of the human pak1 inhibitor (hPIP1) inhibits the ability of agrin to induce acetocholine receptor clustering in vivo
Curated By
- BioGRID