BAIT
HRAS
H-ras, Ha-ras, Harvey-ras, Hras-1, Hras1, Kras2, c-H-ras, c-Ha-ras, c-rasHa, ras
Harvey rat sarcoma virus oncogene
GO Process (33)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- Ras protein signal transduction [ISO, TAS]
- apoptotic process [ISO]
- cell aging [IDA]
- cell cycle arrest [ISO]
- cell proliferation [IPI]
- cellular senescence [ISO]
- endocytosis [IDA]
- intrinsic apoptotic signaling pathway [IGI, IMP]
- mitotic cell cycle checkpoint [ISO]
- negative regulation of Rho GTPase activity [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of neuron apoptotic process [IDA, IGI]
- positive regulation of DNA replication [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of Ras protein signal transduction [ISO]
- positive regulation of actin cytoskeleton reorganization [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IDA, ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of gene expression [IDA]
- positive regulation of miRNA metabolic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of ruffle assembly [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of wound healing [ISO]
- protein heterooligomerization [ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- small GTPase mediated signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TCF4
5730422P05Rik, ASP-I2, E2-2, E2.2, ITF-2, ITF-2b, ITF2, ME2, MITF-2A, MITF-2B, SEF-2, SEF2, SEF2-1, TFE, Tcf-4, bHLHb19
transcription factor 4
GO Process (8)
GO Function (15)
GO Component (2)
Gene Ontology Biological Process
- DNA-templated transcription, initiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of neuron differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein-DNA complex assembly [IDA]
- regulation of transcription, DNA-templated [IDA]
- transcription initiation from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- TFIIB-class binding transcription factor activity [IDA]
- TFIIB-class transcription factor binding [IDA]
- bHLH transcription factor binding [ISO]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding RNA polymerase recruiting transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription corepressor activity [IDA]
- DNA binding [IDA, ISO]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- TFIIB-class binding transcription factor activity [IDA]
- TFIIB-class transcription factor binding [IDA]
- bHLH transcription factor binding [ISO]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding RNA polymerase recruiting transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription corepressor activity [IDA]
Gene Ontology Cellular Component
Mus musculus
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
APC inhibits ERK pathway activation and cellular proliferation induced by RAS.
Inactivating mutations in the adenomatous polyposis coli gene (APC), and activating mutations in RAS, occur in a majority of colorectal carcinomas. However, the relationship between these changes and tumorigenesis is poorly understood. RAS-induced activation of the ERK pathway was reduced by overexpressing APC in DLD-1 colorectal cancer cells. ERK activity was increased by Cre-virus-induced Apc knockout in primary Apc(flox/flox) mouse ... [more]
J. Cell. Sci. Mar. 01, 2006; 119(0);819-27 [Pubmed: 16478791]
Throughput
- Low Throughput
Ontology Terms
- phenotype: abnormal intercellular signaling peptide or protein level (MP:0008835)
Additional Notes
- Co-transfection of tcf4 with Ras decreases ERK pathway activation
Curated By
- BioGRID