BAIT
CDH2
CDHN, N-cadherin, Ncad
cadherin 2
GO Process (19)
GO Function (9)
GO Component (15)
Gene Ontology Biological Process
- blood vessel morphogenesis [IMP]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IDA, ISO]
- cell adhesion [IDA]
- cell migration [IDA]
- cell-cell adhesion mediated by cadherin [IDA]
- glial cell differentiation [IDA]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- homophilic cell adhesion via plasma membrane adhesion molecules [IDA]
- negative regulation of canonical Wnt signaling pathway [IGI]
- neuronal stem cell maintenance [IDA]
- positive regulation of MAPK cascade [IGI]
- protein heterooligomerization [ISO]
- regulation of Rho protein signal transduction [ISO]
- regulation of axonogenesis [ISO]
- regulation of myelination [ISO]
- regulation of protein localization [ISO]
- single organismal cell-cell adhesion [ISO]
- striated muscle cell differentiation [IGI]
- synapse assembly [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISO]
- adherens junction [IDA]
- apical plasma membrane [IDA]
- catenin complex [ISO]
- cell-cell adherens junction [ISO]
- cell-cell junction [IDA, ISO]
- extracellular vesicular exosome [ISO]
- fascia adherens [IDA, ISO]
- focal adhesion [ISO]
- intercalated disc [IDA, ISO]
- lamellipodium [IDA]
- membrane [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- synapse [IDA, ISO]
Mus musculus
PREY
LRP6
C030016K15Rik, Cd, Gw, ska26, ska, skax26
low density lipoprotein receptor-related protein 6
GO Process (91)
GO Function (13)
GO Component (12)
Gene Ontology Biological Process
- Wnt signaling pathway [IGI, ISO]
- Wnt signaling pathway involved in dorsal/ventral axis specification [IBA, ISO]
- Wnt signaling pathway involved in forebrain neuroblast division [IGI, IMP]
- Wnt signaling pathway involved in somitogenesis [IMP]
- anterior/posterior pattern specification [IGI, IMP]
- axis elongation [IMP]
- axis elongation involved in somitogenesis [IGI]
- bone morphogenesis [IMP]
- bone remodeling [IGI]
- branching involved in mammary gland duct morphogenesis [IMP]
- canonical Wnt signaling pathway [IGI, IMP, ISO]
- canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development [IMP]
- canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [IMP]
- cell migration involved in gastrulation [IGI]
- cellular response to cholesterol [ISO]
- cerebellum morphogenesis [IMP]
- cerebral cortex cell migration [IMP]
- cerebral cortex development [IMP]
- convergent extension [IGI]
- dopaminergic neuron differentiation [IMP]
- dorsal/ventral axis specification [IMP]
- embryonic camera-type eye morphogenesis [IMP]
- embryonic digit morphogenesis [IGI, IMP]
- embryonic forelimb morphogenesis [IGI, IMP]
- embryonic hindlimb morphogenesis [IGI, IMP]
- embryonic limb morphogenesis [IGI]
- embryonic pattern specification [IMP]
- embryonic retina morphogenesis in camera-type eye [IMP]
- external genitalia morphogenesis [IMP]
- face morphogenesis [IMP]
- forebrain development [IMP]
- forebrain generation of neurons [IMP]
- forebrain radial glial cell differentiation [IGI]
- formation of radial glial scaffolds [IGI]
- gastrulation with mouth forming second [IGI]
- generation of neurons [IMP]
- heart looping [IGI]
- limb morphogenesis [IGI, IMP]
- mammary gland duct morphogenesis [IGI]
- mammary placode formation [IMP]
- midbrain development [IMP]
- midbrain-hindbrain boundary development [IMP]
- morphogenesis of an epithelium [IMP]
- negative regulation of Wnt signaling pathway [IGI]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of non-canonical Wnt signaling pathway [IGI]
- negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [IGI]
- negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis [IGI]
- negative regulation of planar cell polarity pathway involved in neural tube closure [IGI]
- negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis [IGI]
- negative regulation of planar cell polarity pathway involved in pericardium morphogenesis [IGI]
- negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis [IGI]
- negative regulation of protein kinase activity [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of protein serine/threonine kinase activity [ISO]
- negative regulation of smooth muscle cell apoptotic process [ISO]
- neural crest cell differentiation [ISO]
- neural crest formation [IBA, ISO]
- neural tube closure [IGI, IMP]
- neural tube development [IGI]
- odontogenesis of dentin-containing tooth [IMP]
- palate development [IMP]
- pericardium morphogenesis [IGI]
- positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of bone resorption [IMP]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of cell cycle [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of ossification [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- post-anal tail morphogenesis [IGI, IMP]
- primitive streak formation [IGI]
- receptor-mediated endocytosis [IBA]
- receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [IMP]
- regulation of cell development [IMP]
- regulation of cell proliferation [IMP]
- regulation of transcription, DNA-templated [ISO]
- response to folic acid [IMP]
- retina morphogenesis in camera-type eye [IMP]
- single organismal cell-cell adhesion [ISO]
- skeletal system morphogenesis [IMP]
- somitogenesis [IGI]
- synaptic transmission [IBA, ISO]
- thalamus development [IMP]
- toxin transport [IMP, ISO]
- trachea cartilage morphogenesis [IGI]
Gene Ontology Molecular Function- Wnt-activated receptor activity [IBA]
- Wnt-protein binding [IPI, ISO]
- apolipoprotein binding [IPI]
- coreceptor activity [IBA]
- coreceptor activity involved in Wnt signaling pathway [ISO]
- frizzled binding [ISO]
- identical protein binding [ISO]
- kinase inhibitor activity [ISO]
- low-density lipoprotein receptor activity [IBA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- toxin transporter activity [IMP]
- Wnt-activated receptor activity [IBA]
- Wnt-protein binding [IPI, ISO]
- apolipoprotein binding [IPI]
- coreceptor activity [IBA]
- coreceptor activity involved in Wnt signaling pathway [ISO]
- frizzled binding [ISO]
- identical protein binding [ISO]
- kinase inhibitor activity [ISO]
- low-density lipoprotein receptor activity [IBA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- toxin transporter activity [IMP]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- caveola [IBA, ISO]
- cell [IMP]
- cell surface [IBA, ISO]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- early endosome [IDA, ISO]
- membrane [IDA]
- neuronal cell body [IBA, ISO]
- plasma membrane [IDA, IGI, ISO]
- receptor complex [IBA]
- synapse [IBA, ISO]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation.
Wnt signaling plays an important role in the regulation of bone formation and bone mass. The mechanisms that regulate canonical Wnt signaling in osteoblasts are not fully understood. We show here a novel mechanism by which the adhesion molecule N-cadherin interacts with the Wnt coreceptor LRP5 and regulates canonical Wnt/beta-catenin signaling in osteoblasts. We demonstrate that N-cadherin, besides associating with ... [more]
Mol. Cell. Biol. Feb. 01, 2009; 29(4);953-64 [Pubmed: 19075000]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDH2 LRP6 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 502958 |
Curated By
- BioGRID