BAIT
CDH2
CDHN, N-cadherin, Ncad
cadherin 2
GO Process (19)
GO Function (9)
GO Component (15)
Gene Ontology Biological Process
- blood vessel morphogenesis [IMP]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IDA, ISO]
- cell adhesion [IDA]
- cell migration [IDA]
- cell-cell adhesion mediated by cadherin [IDA]
- glial cell differentiation [IDA]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- homophilic cell adhesion via plasma membrane adhesion molecules [IDA]
- negative regulation of canonical Wnt signaling pathway [IGI]
- neuronal stem cell maintenance [IDA]
- positive regulation of MAPK cascade [IGI]
- protein heterooligomerization [ISO]
- regulation of Rho protein signal transduction [ISO]
- regulation of axonogenesis [ISO]
- regulation of myelination [ISO]
- regulation of protein localization [ISO]
- single organismal cell-cell adhesion [ISO]
- striated muscle cell differentiation [IGI]
- synapse assembly [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISO]
- adherens junction [IDA]
- apical plasma membrane [IDA]
- catenin complex [ISO]
- cell-cell adherens junction [ISO]
- cell-cell junction [IDA, ISO]
- extracellular vesicular exosome [ISO]
- fascia adherens [IDA, ISO]
- focal adhesion [ISO]
- intercalated disc [IDA, ISO]
- lamellipodium [IDA]
- membrane [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- synapse [IDA, ISO]
Mus musculus
PREY
WNT3A
Wnt-3a, vt, RP23-378H5.2
wingless-type MMTV integration site family, member 3A
GO Process (66)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- COP9 signalosome assembly [IDA]
- Wnt signaling pathway [IGI]
- Wnt signaling pathway involved in forebrain neuroblast division [IMP]
- anterior/posterior pattern specification [IDA]
- axis elongation involved in somitogenesis [IGI]
- axon guidance [IDA]
- axonogenesis [IDA, IGI]
- canonical Wnt signaling pathway [IDA, IGI, IMP, ISO]
- canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [ISO]
- cardiac muscle cell fate commitment [IGI]
- cell proliferation in forebrain [IDA]
- cell-cell signaling [TAS]
- cellular protein localization [IDA]
- determination of left/right symmetry [IMP]
- dorsal/ventral neural tube patterning [IMP]
- extracellular matrix organization [IDA]
- heart looping [IMP]
- hemopoiesis [IDA]
- hippocampus development [IMP]
- in utero embryonic development [IMP]
- inner ear morphogenesis [IGI]
- mammary gland development [IDA]
- mesoderm development [IMP]
- negative regulation of axon extension involved in axon guidance [IDA]
- negative regulation of fat cell differentiation [IDA, IGI]
- negative regulation of heart induction by canonical Wnt signaling pathway [ISO]
- negative regulation of neurogenesis [IDA]
- negative regulation of neuron projection development [IDA]
- organ morphogenesis [TAS]
- osteoblast differentiation [IGI]
- palate development [ISO]
- paraxial mesodermal cell fate commitment [IMP]
- platelet activation [IDA]
- platelet aggregation [IDA]
- positive regulation of B cell proliferation [IDA]
- positive regulation of canonical Wnt signaling pathway [IDA, ISO]
- positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation [IDA]
- positive regulation of cardiac muscle cell differentiation [ISO]
- positive regulation of catenin import into nucleus [ISO]
- positive regulation of cell proliferation [IDA]
- positive regulation of cell-cell adhesion mediated by cadherin [IDA]
- positive regulation of collateral sprouting in absence of injury [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of cytokine production [IDA]
- positive regulation of dermatome development [ISO]
- positive regulation of mesodermal cell fate specification [ISO]
- positive regulation of neural precursor cell proliferation [IDA]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein tyrosine kinase activity [IGI]
- positive regulation of receptor activity [ISO]
- positive regulation of receptor internalization [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- post-anal tail morphogenesis [IMP]
- regulation of axonogenesis [IGI]
- regulation of cell differentiation [IDA]
- regulation of microtubule cytoskeleton organization [IGI]
- signal transduction [TAS]
- skeletal muscle cell differentiation [IGI]
- somatic stem cell division [IDA]
- somitogenesis [IMP]
- spinal cord association neuron differentiation [IDA, IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation.
Wnt signaling plays an important role in the regulation of bone formation and bone mass. The mechanisms that regulate canonical Wnt signaling in osteoblasts are not fully understood. We show here a novel mechanism by which the adhesion molecule N-cadherin interacts with the Wnt coreceptor LRP5 and regulates canonical Wnt/beta-catenin signaling in osteoblasts. We demonstrate that N-cadherin, besides associating with ... [more]
Mol. Cell. Biol. Feb. 01, 2009; 29(4);953-64 [Pubmed: 19075000]
Throughput
- Low Throughput
Curated By
- BioGRID