BAIT
CTNNB1
Bfc, Catnb, Mesc
catenin (cadherin associated protein), beta 1
GO Process (137)
GO Function (14)
GO Component (29)
Gene Ontology Biological Process
- T cell differentiation [IMP]
- T cell differentiation in thymus [IMP]
- Wnt signaling pathway [IDA]
- adherens junction organization [IMP]
- anterior/posterior axis specification [IMP]
- bone resorption [IGI, IMP]
- branching involved in ureteric bud morphogenesis [IMP]
- canonical Wnt signaling pathway [IDA, IGI, IMP]
- canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [IMP]
- cardiac muscle cell proliferation [TAS]
- cardiac vascular smooth muscle cell differentiation [TAS]
- cell differentiation [IMP]
- cell fate determination [IMP]
- cell fate specification [IMP]
- cell maturation [IDA, IMP]
- cell morphogenesis involved in differentiation [IMP]
- cell proliferation [IMP]
- cell-matrix adhesion [IMP]
- cellular process [IDA]
- cellular protein localization [IMP]
- cellular response to organic cyclic compound [IDA]
- central nervous system vasculogenesis [IMP]
- chromatin-mediated maintenance of transcription [IMP]
- coronary artery morphogenesis [TAS]
- dorsal/ventral axis specification [IMP]
- dorsal/ventral pattern formation [IMP]
- ectoderm development [IMP]
- embryonic axis specification [IDA]
- embryonic digit morphogenesis [IGI, IMP]
- embryonic foregut morphogenesis [IMP]
- embryonic forelimb morphogenesis [IDA]
- embryonic heart tube development [IMP]
- embryonic hindlimb morphogenesis [IMP]
- embryonic skeletal limb joint morphogenesis [IGI]
- endoderm formation [IMP]
- endodermal cell fate commitment [IMP]
- epicardium-derived cardiac vascular smooth muscle cell differentiation [TAS]
- epithelial cell differentiation involved in prostate gland development [IMP]
- epithelial tube branching involved in lung morphogenesis [IMP]
- forebrain development [IMP]
- fungiform papilla formation [IMP]
- gastrulation with mouth forming second [IMP]
- genitalia morphogenesis [IMP]
- glial cell fate determination [IDA]
- hair cycle process [IMP]
- hair follicle morphogenesis [IMP]
- hair follicle placode formation [IGI, IMP]
- heart development [IMP]
- hemopoiesis [IDA]
- in utero embryonic development [IGI, IMP]
- kidney development [IMP]
- layer formation in cerebral cortex [IMP]
- lens morphogenesis in camera-type eye [IMP]
- limb development [IMP]
- lung cell differentiation [IMP]
- lung development [IMP]
- lung induction [IMP]
- lung-associated mesenchyme development [IMP]
- male genitalia development [IMP]
- mesenchymal cell proliferation involved in lung development [IMP]
- mesenchymal to epithelial transition involved in metanephros morphogenesis [IDA]
- mesenchyme development [TAS]
- mesenchyme morphogenesis [TAS]
- metanephros morphogenesis [IMP]
- morphogenesis of embryonic epithelium [IMP]
- negative regulation of apoptotic signaling pathway [IGI, IMP]
- negative regulation of cell differentiation [IMP]
- negative regulation of chondrocyte differentiation [IGI]
- negative regulation of mitotic cell cycle, embryonic [IMP]
- negative regulation of neuron death [IGI]
- negative regulation of oligodendrocyte differentiation [IMP]
- negative regulation of osteoclast differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- nephron tubule formation [IMP]
- neural plate development [IDA]
- neuron migration [IGI]
- odontogenesis of dentin-containing tooth [IMP]
- oocyte development [IGI]
- organ development [IMP]
- osteoclast differentiation [IMP]
- oviduct development [IMP]
- pancreas development [IMP]
- patterning of blood vessels [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of MAPK cascade [IGI]
- positive regulation of branching involved in lung morphogenesis [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of determination of dorsal identity [IDA]
- positive regulation of endothelial cell differentiation [IMP]
- positive regulation of epithelial cell differentiation [IMP]
- positive regulation of epithelial cell proliferation involved in prostate gland development [IMP]
- positive regulation of epithelial to mesenchymal transition [ISO, TAS]
- positive regulation of fibroblast growth factor receptor signaling pathway [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of neuroblast proliferation [IGI, IMP]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of telomerase activity [IMP]
- positive regulation of telomere maintenance via telomerase [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- proximal/distal pattern formation [IMP]
- regulation of T cell proliferation [IMP]
- regulation of apoptotic process [IMP]
- regulation of cell differentiation [IDA]
- regulation of cell fate specification [IBA]
- regulation of cell proliferation [IDA, IMP]
- regulation of centromeric sister chromatid cohesion [IMP]
- regulation of epithelial cell differentiation [IMP]
- regulation of gene expression [IMP]
- regulation of myelination [IMP]
- regulation of nephron tubule epithelial cell differentiation [IMP]
- regulation of osteoblast differentiation [IMP]
- regulation of osteoclast differentiation [IMP]
- regulation of secondary heart field cardioblast proliferation [IDA]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription, DNA-templated [IDA]
- renal inner medulla development [IMP]
- renal outer medulla development [IMP]
- renal system development [IMP]
- renal vesicle formation [IMP]
- single organismal cell-cell adhesion [IMP]
- skeletal system development [IMP]
- skin development [IMP]
- smooth muscle cell differentiation [IMP]
- stem cell maintenance [TAS]
- sympathetic ganglion development [IMP]
- synapse organization [IMP]
- synaptic transmission [IMP]
- synaptic vesicle transport [IMP]
- thymus development [IMP]
- trachea formation [IMP]
- trachea morphogenesis [IMP]
- vasculature development [IMP]
- vasculogenesis [IMP]
- ventricular compact myocardium morphogenesis [TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- alpha-catenin binding [IDA, IPI]
- cadherin binding [IPI, ISO]
- chromatin binding [IDA, IGI]
- double-stranded DNA binding [IDA]
- euchromatin binding [IDA]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- alpha-catenin binding [IDA, IPI]
- cadherin binding [IPI, ISO]
- chromatin binding [IDA, IGI]
- double-stranded DNA binding [IDA]
- euchromatin binding [IDA]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
- Scrib-APC-beta-catenin complex [IDA]
- Z disc [IDA]
- adherens junction [IDA]
- apical junction complex [IDA]
- apical part of cell [IDA]
- basolateral plasma membrane [IDA]
- beta-catenin destruction complex [IDA]
- catenin complex [IBA]
- catenin-TCF7L2 complex [IDA]
- cell [IMP]
- cell projection membrane [IDA]
- cell-cell adherens junction [IDA]
- cell-cell junction [IDA, ISO]
- centrosome [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- fascia adherens [IDA]
- intercalated disc [IDA]
- lamellipodium [IDA]
- lateral plasma membrane [IDA, ISO]
- membrane [IDA]
- microvillus membrane [IDA]
- nuclear euchromatin [IDA]
- nuclear transcription factor complex [IDA]
- nucleus [IDA]
- plasma membrane [IDA]
- protein complex [ISO]
- tight junction [IDA]
- transcription factor complex [IDA]
Mus musculus
PREY
LEF1
3000002B05, AI451430, Lef-1
lymphoid enhancer binding factor 1
GO Process (74)
GO Function (22)
GO Component (4)
Gene Ontology Biological Process
- B cell proliferation [IMP]
- BMP signaling pathway [IDA]
- T cell receptor V(D)J recombination [IGI]
- T-helper 1 cell differentiation [IDA]
- Wnt signaling pathway [IDA, IGI, IMP, ISO]
- alpha-beta T cell differentiation [IGI]
- anatomical structure regression [IMP]
- apoptotic process involved in morphogenesis [IMP]
- apoptotic process involved in patterning of blood vessels [IMP]
- canonical Wnt signaling pathway [IBA, ISO]
- cell chemotaxis [ISO]
- cell development [IGI]
- cellular response to cytokine stimulus [ISO]
- cellular response to interleukin-4 [ISO]
- chorio-allantoic fusion [IGI]
- dentate gyrus development [IMP]
- embryonic limb morphogenesis [IGI]
- epithelial to mesenchymal transition [IMP]
- eye pigmentation [IBA]
- face morphogenesis [IGI]
- forebrain neuroblast division [IGI]
- forebrain neuron differentiation [IBA]
- forebrain radial glial cell differentiation [IGI]
- formation of radial glial scaffolds [IGI]
- hippocampus development [IMP]
- histone H3 acetylation [ISO]
- histone H4 acetylation [ISO]
- hypothalamus development [IBA]
- mammary gland development [IMP]
- muscle fiber development [IBA]
- negative regulation of DNA binding [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of apoptotic process in bone marrow [IBA, ISO]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IBA, ISO]
- negative regulation of estrogen receptor binding [ISO]
- negative regulation of interleukin-13 production [IBA, ISO]
- negative regulation of interleukin-4 production [IBA, ISO]
- negative regulation of interleukin-5 production [IBA, ISO]
- negative regulation of striated muscle tissue development [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- neural crest cell migration [IBA]
- neutrophil differentiation [IBA, ISO]
- odontoblast differentiation [IBA, ISO]
- odontogenesis of dentin-containing tooth [IGI, IMP]
- osteoblast differentiation [IBA]
- palate development [IMP]
- paraxial mesoderm formation [IGI]
- patterning of blood vessels [IMP]
- positive regulation by host of viral transcription [ISO]
- positive regulation of cell cycle process [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell proliferation in bone marrow [IBA, ISO]
- positive regulation of cell-cell adhesion [ISO]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of granulocyte differentiation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO]
- regulation of Wnt signaling pathway [IGI]
- regulation of cell-cell adhesion [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- sensory perception of taste [IMP]
- somitogenesis [IGI, IMP]
- sprouting angiogenesis [IMP]
- steroid hormone mediated signaling pathway [ISO]
- tongue development [IMP]
- trachea gland development [IMP]
- transcription from RNA polymerase II promoter [IGI, ISO]
- vasculature development [IMP]
Gene Ontology Molecular Function- C2H2 zinc finger domain binding [ISO]
- DNA binding [IDA]
- DNA binding, bending [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IGI]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- armadillo repeat domain binding [IBA, ISO]
- beta-catenin binding [IBA, ISO]
- chromatin binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- enhancer binding [IBA, ISO]
- estrogen receptor activity [ISO]
- estrogen receptor binding [IBA, ISO]
- gamma-catenin binding [IBA, ISO]
- histone binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IBA, IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA, ISO]
- C2H2 zinc finger domain binding [ISO]
- DNA binding [IDA]
- DNA binding, bending [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IGI]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- armadillo repeat domain binding [IBA, ISO]
- beta-catenin binding [IBA, ISO]
- chromatin binding [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- enhancer binding [IBA, ISO]
- estrogen receptor activity [ISO]
- estrogen receptor binding [IBA, ISO]
- gamma-catenin binding [IBA, ISO]
- histone binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IBA, IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA, ISO]
Mus musculus
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination.
While the biological roles of canonical Wnt/beta-catenin signaling in development and disease are well documented, understanding the molecular logic underlying the functionally distinct nuclear transcriptional programs mediating the diverse functions of beta-catenin remains a major challenge. Here, we report an unexpected strategy for beta-catenin-dependent regulation of cell-lineage determination based on interactions between beta-catenin and a specific homeodomain factor, Prop1, rather ... [more]
Cell May. 05, 2006; 125(3);593-605 [Pubmed: 16678101]
Throughput
- Low Throughput
Ontology Terms
- phenotype: abnormal protein level (MP:0008469)
Additional Notes
- genetic complex
- overexpression of Lef1 represses the high expression levels of Pit1 and a minimal reporter seen upon expression of beta-catenin and prop1
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CTNNB1 LEF1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 658052 | |
| LEF1 CTNNB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 658246 | |
| LEF1 CTNNB1 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 658564 | |
| LEF1 CTNNB1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID