FZD8
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IBA]
- T cell differentiation in thymus [IMP]
- Wnt signaling pathway [IDA]
- angiogenesis [IDA]
- canonical Wnt signaling pathway [IDA, IGI, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- non-canonical Wnt signaling pathway [IBA]
- positive regulation of JUN kinase activity [IDA]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- signal transduction [IPI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RYK
Gene Ontology Biological Process
- Wnt signaling pathway [IDA, IGI]
- axon guidance [IDA, IMP]
- axonogenesis [IGI]
- commissural neuron axon guidance [IMP]
- corpus callosum development [IMP]
- negative chemotaxis [IGI]
- negative regulation of axon extension involved in axon guidance [IGI]
- neuron differentiation [IDA]
- neuron projection development [IMP]
- positive regulation of MAPK cascade [ISO]
- signal transduction [IPI]
- skeletal system morphogenesis [IMP]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.
The Ryk receptor belongs to the atypical receptor tyrosine kinase family. It is a new member of the family of Wnt receptor proteins. However, the molecular mechanisms by which the Ryk receptor functions remain unknown. Here, we report that mammalian Ryk, unlike the Drosophila Ryk homolog Derailed, functions as a coreceptor along with Frizzled for Wnt ligands. Ryk also binds ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID