FZD1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IBA]
- Wnt signaling pathway [IGI, ISO]
- autocrine signaling [ISO]
- canonical Wnt signaling pathway [IMP, ISO]
- canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation [ISO]
- canonical Wnt signaling pathway involved in osteoblast differentiation [ISO]
- cell-cell signaling [IDA, ISO]
- epithelial cell differentiation [IDA, IGI]
- hard palate development [IGI]
- membranous septum morphogenesis [IGI]
- muscular septum morphogenesis [IGI]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of catenin import into nucleus [IDA]
- negative regulation of transcription, DNA-templated [IMP]
- outflow tract morphogenesis [IGI]
- planar cell polarity pathway involved in neural tube closure [IGI]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- response to drug [ISO]
- ventricular septum morphogenesis [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
WNT7B
Gene Ontology Biological Process
- Wnt signaling pathway [IGI, IMP]
- activation of JUN kinase activity [ISO]
- anatomical structure regression [IMP]
- angiogenesis [IGI, IMP]
- apoptotic process involved in patterning of blood vessels [IMP]
- canonical Wnt signaling pathway [IDA, IGI, IMP]
- cell fate commitment [IBA]
- cell proliferation in forebrain [IDA]
- cellular metabolic process [IMP]
- central nervous system vasculogenesis [IGI]
- chorio-allantoic fusion [IMP]
- developmental growth involved in morphogenesis [IMP]
- embryonic organ development [IMP]
- embryonic placenta morphogenesis [IMP]
- establishment or maintenance of polarity of embryonic epithelium [IMP]
- homeostatic process [IMP]
- in utero embryonic development [IMP]
- inner medullary collecting duct development [IMP]
- lobar bronchus development [IMP]
- lung development [IMP]
- lung epithelium development [IMP]
- lung morphogenesis [IMP]
- lung-associated mesenchyme development [IMP]
- metanephric collecting duct development [IMP]
- metanephric epithelium development [IMP]
- metanephric loop of Henle development [IMP]
- metanephros morphogenesis [IMP]
- negative regulation of neurogenesis [IDA]
- negative regulation of smoothened signaling pathway [IMP]
- neuron differentiation [IBA]
- neuron projection development [ISO]
- neuron projection morphogenesis [ISO]
- odontogenesis of dentin-containing tooth [IMP]
- outer medullary collecting duct development [IMP]
- oxygen homeostasis [IMP]
- positive regulation of JNK cascade [IBA, ISO]
- positive regulation of cell proliferation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of receptor activity [IC]
- regulation of cell projection size [ISO]
- renal inner medulla development [IMP]
- renal outer medulla development [IMP]
- signal transduction [IC]
- smooth muscle cell differentiation [IMP]
- stem cell development [IDA]
- synapse organization [IGI]
- trachea cartilage morphogenesis [IMP]
- vasculature development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5.
Wnt7b is a Wnt ligand that has been demonstrated to play critical roles in several developmental processes, including lung airway and vascular development and chorion-allantois fusion during placental development. Wnt signaling involves the binding of Wnt ligands to cell surface receptors of the frizzled family and coreceptors of the LRP5/6 family. However, little is known of the ligand-receptor specificity exhibited ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| WNT7B FZD1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 503088 |
Curated By
- BioGRID