BAIT
LRP6
C030016K15Rik, Cd, Gw, ska26, ska, skax26
low density lipoprotein receptor-related protein 6
GO Process (91)
GO Function (13)
GO Component (12)
Gene Ontology Biological Process
- Wnt signaling pathway [IGI, ISO]
- Wnt signaling pathway involved in dorsal/ventral axis specification [IBA, ISO]
- Wnt signaling pathway involved in forebrain neuroblast division [IGI, IMP]
- Wnt signaling pathway involved in somitogenesis [IMP]
- anterior/posterior pattern specification [IGI, IMP]
- axis elongation [IMP]
- axis elongation involved in somitogenesis [IGI]
- bone morphogenesis [IMP]
- bone remodeling [IGI]
- branching involved in mammary gland duct morphogenesis [IMP]
- canonical Wnt signaling pathway [IGI, IMP, ISO]
- canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development [IMP]
- canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [IMP]
- cell migration involved in gastrulation [IGI]
- cellular response to cholesterol [ISO]
- cerebellum morphogenesis [IMP]
- cerebral cortex cell migration [IMP]
- cerebral cortex development [IMP]
- convergent extension [IGI]
- dopaminergic neuron differentiation [IMP]
- dorsal/ventral axis specification [IMP]
- embryonic camera-type eye morphogenesis [IMP]
- embryonic digit morphogenesis [IGI, IMP]
- embryonic forelimb morphogenesis [IGI, IMP]
- embryonic hindlimb morphogenesis [IGI, IMP]
- embryonic limb morphogenesis [IGI]
- embryonic pattern specification [IMP]
- embryonic retina morphogenesis in camera-type eye [IMP]
- external genitalia morphogenesis [IMP]
- face morphogenesis [IMP]
- forebrain development [IMP]
- forebrain generation of neurons [IMP]
- forebrain radial glial cell differentiation [IGI]
- formation of radial glial scaffolds [IGI]
- gastrulation with mouth forming second [IGI]
- generation of neurons [IMP]
- heart looping [IGI]
- limb morphogenesis [IGI, IMP]
- mammary gland duct morphogenesis [IGI]
- mammary placode formation [IMP]
- midbrain development [IMP]
- midbrain-hindbrain boundary development [IMP]
- morphogenesis of an epithelium [IMP]
- negative regulation of Wnt signaling pathway [IGI]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of non-canonical Wnt signaling pathway [IGI]
- negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [IGI]
- negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis [IGI]
- negative regulation of planar cell polarity pathway involved in neural tube closure [IGI]
- negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis [IGI]
- negative regulation of planar cell polarity pathway involved in pericardium morphogenesis [IGI]
- negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis [IGI]
- negative regulation of protein kinase activity [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of protein serine/threonine kinase activity [ISO]
- negative regulation of smooth muscle cell apoptotic process [ISO]
- neural crest cell differentiation [ISO]
- neural crest formation [IBA, ISO]
- neural tube closure [IGI, IMP]
- neural tube development [IGI]
- odontogenesis of dentin-containing tooth [IMP]
- palate development [IMP]
- pericardium morphogenesis [IGI]
- positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of bone resorption [IMP]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of cell cycle [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of ossification [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- post-anal tail morphogenesis [IGI, IMP]
- primitive streak formation [IGI]
- receptor-mediated endocytosis [IBA]
- receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport [IMP]
- regulation of cell development [IMP]
- regulation of cell proliferation [IMP]
- regulation of transcription, DNA-templated [ISO]
- response to folic acid [IMP]
- retina morphogenesis in camera-type eye [IMP]
- single organismal cell-cell adhesion [ISO]
- skeletal system morphogenesis [IMP]
- somitogenesis [IGI]
- synaptic transmission [IBA, ISO]
- thalamus development [IMP]
- toxin transport [IMP, ISO]
- trachea cartilage morphogenesis [IGI]
Gene Ontology Molecular Function- Wnt-activated receptor activity [IBA]
- Wnt-protein binding [IPI, ISO]
- apolipoprotein binding [IPI]
- coreceptor activity [IBA]
- coreceptor activity involved in Wnt signaling pathway [ISO]
- frizzled binding [ISO]
- identical protein binding [ISO]
- kinase inhibitor activity [ISO]
- low-density lipoprotein receptor activity [IBA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- toxin transporter activity [IMP]
- Wnt-activated receptor activity [IBA]
- Wnt-protein binding [IPI, ISO]
- apolipoprotein binding [IPI]
- coreceptor activity [IBA]
- coreceptor activity involved in Wnt signaling pathway [ISO]
- frizzled binding [ISO]
- identical protein binding [ISO]
- kinase inhibitor activity [ISO]
- low-density lipoprotein receptor activity [IBA, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [ISO]
- toxin transporter activity [IMP]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- caveola [IBA, ISO]
- cell [IMP]
- cell surface [IBA, ISO]
- cytoplasmic vesicle [ISO]
- cytosol [ISO]
- early endosome [IDA, ISO]
- membrane [IDA]
- neuronal cell body [IBA, ISO]
- plasma membrane [IDA, IGI, ISO]
- receptor complex [IBA]
- synapse [IBA, ISO]
Mus musculus
PREY
WNT5A
8030457G12Rik, Wnt-5a, RP24-345B5.1
wingless-type MMTV integration site family, member 5A
GO Process (126)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- JNK cascade [IDA]
- Wnt signaling pathway [IGI, ISO]
- Wnt signaling pathway, calcium modulating pathway [IDA, IMP, ISO]
- Wnt signaling pathway, planar cell polarity pathway [IDA, IGI, IMP, ISO]
- activation of JUN kinase activity [ISO]
- activation of MAPK activity [ISO]
- activation of protein kinase B activity [ISO]
- ameboidal-type cell migration [IMP]
- anterior/posterior axis specification, embryo [IDA]
- anterior/posterior pattern specification [IMP]
- axis elongation [IMP]
- axon guidance [IDA]
- canonical Wnt signaling pathway [IDA, IGI, IMP]
- cell fate commitment [IBA]
- cell migration [IGI, IMP]
- cell-cell signaling [TAS]
- cellular protein localization [IMP, ISO]
- cellular response to molecule of bacterial origin [IDA]
- cervix development [IMP]
- cochlea morphogenesis [IGI, IMP]
- convergent extension [IMP]
- convergent extension involved in organogenesis [IGI]
- determination of left/right symmetry [IMP]
- development of primary male sexual characteristics [IMP]
- digestive tract morphogenesis [IMP]
- dopaminergic neuron differentiation [IGI, IMP]
- embryo development [IMP]
- embryonic digit morphogenesis [IMP]
- embryonic limb morphogenesis [IMP]
- embryonic skeletal system development [ISO]
- epithelial cell proliferation involved in mammary gland duct elongation [IDA]
- establishment of planar polarity [IMP]
- face development [ISO]
- genitalia development [ISO]
- heart looping [IGI]
- hematopoietic stem cell proliferation [IDA, IMP, ISO]
- hindgut morphogenesis [IMP]
- hypophysis morphogenesis [IMP]
- inner ear morphogenesis [IDA, IMP]
- lateral sprouting involved in mammary gland duct morphogenesis [IDA]
- limb morphogenesis [IMP]
- lung development [IMP]
- male gonad development [IMP]
- mammary gland branching involved in thelarche [IDA]
- mesenchymal-epithelial cell signaling [IMP]
- midgut development [IMP]
- morphogenesis of an epithelium [IMP]
- negative chemotaxis [IGI]
- negative regulation of BMP signaling pathway [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of axon extension involved in axon guidance [IGI]
- negative regulation of canonical Wnt signaling pathway [IDA, IGI, IMP, ISO]
- negative regulation of epithelial cell proliferation [IDA, IMP]
- negative regulation of fat cell differentiation [ISO]
- negative regulation of fibroblast growth factor receptor signaling pathway [IMP]
- negative regulation of mesenchymal cell proliferation [ISO]
- negative regulation of prostatic bud formation [IMP]
- negative regulation of synapse assembly [IDA]
- negative regulation of transcription, DNA-templated [ISO]
- neural tube closure [IGI]
- neural tube development [IGI]
- neuron projection morphogenesis [IDA]
- non-canonical Wnt signaling pathway [IDA]
- non-canonical Wnt signaling pathway via JNK cascade [IMP]
- olfactory bulb interneuron development [IMP]
- organ morphogenesis [TAS]
- palate development [ISO]
- pericardium morphogenesis [IGI]
- planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [IMP]
- planar cell polarity pathway involved in cardiac right atrium morphogenesis [IMP]
- planar cell polarity pathway involved in neural tube closure [IMP]
- planar cell polarity pathway involved in outflow tract morphogenesis [IMP]
- planar cell polarity pathway involved in pericardium morphogenesis [IMP]
- planar cell polarity pathway involved in ventricular septum morphogenesis [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of JUN kinase activity [IDA, IMP]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of T cell chemotaxis [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of cGMP metabolic process [ISO]
- positive regulation of cartilage development [IDA, IMP]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of cell-cell adhesion [ISO]
- positive regulation of cell-cell adhesion mediated by cadherin [IDA]
- positive regulation of chemokine biosynthetic process [ISO]
- positive regulation of cytokine production [IDA]
- positive regulation of cytokine secretion involved in immune response [ISO]
- positive regulation of endocytosis [IDA]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of inflammatory response [ISO]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-1 beta secretion [IDA, ISO]
- positive regulation of interleukin-6 production [IDA, ISO]
- positive regulation of interleukin-8 secretion [IDA]
- positive regulation of macrophage activation [ISO]
- positive regulation of macrophage cytokine production [ISO]
- positive regulation of meiosis [IGI]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of neuron projection development [IDA]
- positive regulation of ossification [ISO]
- positive regulation of peptidyl-serine phosphorylation [IGI]
- positive regulation of peptidyl-threonine phosphorylation [IGI]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein kinase C signaling [ISO]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of response to cytokine stimulus [ISO]
- positive regulation of thymocyte apoptotic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of type I interferon-mediated signaling pathway [ISO]
- post-anal tail morphogenesis [IGI, IMP]
- primitive streak formation [IGI]
- protein phosphorylation [IGI]
- regulation of branching involved in mammary gland duct morphogenesis [IDA, IGI]
- regulation of protein localization [IDA]
- signal transduction [TAS]
- somitogenesis [IGI]
- tube closure [IMP]
- type B pancreatic cell development [IMP]
- urinary bladder development [IMP]
- uterus development [IMP]
- vagina development [IMP]
- wound healing [ISO]
Gene Ontology Molecular Function- cytokine activity [IDA]
- frizzled binding [IPI, ISO]
- frizzled-2 binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- receptor binding [IPI, TAS]
- receptor tyrosine kinase-like orphan receptor binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription regulatory region DNA binding [ISO]
- cytokine activity [IDA]
- frizzled binding [IPI, ISO]
- frizzled-2 binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- receptor binding [IPI, TAS]
- receptor tyrosine kinase-like orphan receptor binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo.
Lrp5/6 are crucial coreceptors for Wnt/beta-catenin signaling, a pathway biochemically distinct from noncanonical Wnt signaling pathways. Here, we examined the possible participation of Lrp5/6 in noncanonical Wnt signaling. We found that Lrp6 physically interacts with Wnt5a, but that this does not lead to phosphorylation of Lrp6 or activation of the Wnt/beta-catenin pathway. Overexpression of Lrp6 blocks activation of the Wnt5a ... [more]
Mol. Biol. Cell Feb. 01, 2009; 20(3);924-36 [Pubmed: 19056682]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| WNT5A LRP6 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| LRP6 WNT5A | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 503099 |
Curated By
- BioGRID