BAIT
SOX10
Dom, Sox21
SRY (sex determining region Y)-box 10
GO Process (19)
GO Function (12)
GO Component (3)
Gene Ontology Biological Process
- cell differentiation [IMP]
- cell maturation [IGI, IMP]
- developmental growth [IMP]
- digestive tract morphogenesis [IGI, IMP]
- enteric nervous system development [IMP]
- in utero embryonic development [IGI]
- melanocyte differentiation [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of transcription, DNA-templated [ISO]
- neural crest cell migration [IMP]
- oligodendrocyte differentiation [IMP]
- peripheral nervous system development [IGI]
- positive regulation of gliogenesis [IMP]
- positive regulation of neuroblast proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO]
- regulation of transcription, DNA-templated [ISO]
- transcription from RNA polymerase II promoter [IGI]
Gene Ontology Molecular Function
- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IGI]
- chromatin binding [IDA]
- identical protein binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IMP]
- transcription factor binding [IDA, ISO]
- transcription regulatory region DNA binding [IDA]
Mus musculus
PREY
PAX3
Pax-3, Sp, splotch
paired box 3
GO Process (20)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- cardiac muscle cell differentiation [NAS]
- cell migration [IMP]
- cell proliferation [IMP]
- developmental pigmentation [IMP]
- heart development [IMP]
- mammary gland specification [IMP]
- muscle organ development [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- neural crest cell migration [IMP]
- neural tube closure [IMP]
- neural tube development [IGI]
- neuron fate commitment [IGI]
- positive regulation of cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of somitogenesis [IGI, IMP]
- regulation of transcription, DNA-templated [TAS]
- skeletal muscle cell differentiation [NAS]
- spinal cord association neuron differentiation [IGI]
- transcription from RNA polymerase II promoter [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Pax3 functions at a nodal point in melanocyte stem cell differentiation.
Most stem cells are not totipotent. Instead, they are partially committed but remain undifferentiated. Upon appropriate stimulation they are capable of regenerating mature cell types. Little is known about the genetic programmes that maintain the undifferentiated phenotype of lineage-restricted stem cells. Here we describe the molecular details of a nodal point in adult melanocyte stem cell differentiation in which Pax3 ... [more]
Nature Feb. 24, 2005; 433(7028);884-7 [Pubmed: 15729346]
Throughput
- Low Throughput
Ontology Terms
- abnormal protein level (MP:0008469)
Additional Notes
- expression of Pax3 represses the induction of a Dct reporter seen in Sox10/Mitf double mutants
- genetic complex
Curated By
- BioGRID