BAIT
PAX3
Pax-3, Sp, splotch
paired box 3
GO Process (20)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- cardiac muscle cell differentiation [NAS]
- cell migration [IMP]
- cell proliferation [IMP]
- developmental pigmentation [IMP]
- heart development [IMP]
- mammary gland specification [IMP]
- muscle organ development [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI]
- neural crest cell migration [IMP]
- neural tube closure [IMP]
- neural tube development [IGI]
- neuron fate commitment [IGI]
- positive regulation of cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of somitogenesis [IGI, IMP]
- regulation of transcription, DNA-templated [TAS]
- skeletal muscle cell differentiation [NAS]
- spinal cord association neuron differentiation [IGI]
- transcription from RNA polymerase II promoter [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CTNNB1
Bfc, Catnb, Mesc
catenin (cadherin associated protein), beta 1
GO Process (137)
GO Function (14)
GO Component (29)
Gene Ontology Biological Process
- T cell differentiation [IMP]
- T cell differentiation in thymus [IMP]
- Wnt signaling pathway [IDA]
- adherens junction organization [IMP]
- anterior/posterior axis specification [IMP]
- bone resorption [IGI, IMP]
- branching involved in ureteric bud morphogenesis [IMP]
- canonical Wnt signaling pathway [IDA, IGI, IMP]
- canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [IMP]
- cardiac muscle cell proliferation [TAS]
- cardiac vascular smooth muscle cell differentiation [TAS]
- cell differentiation [IMP]
- cell fate determination [IMP]
- cell fate specification [IMP]
- cell maturation [IDA, IMP]
- cell morphogenesis involved in differentiation [IMP]
- cell proliferation [IMP]
- cell-matrix adhesion [IMP]
- cellular process [IDA]
- cellular protein localization [IMP]
- cellular response to organic cyclic compound [IDA]
- central nervous system vasculogenesis [IMP]
- chromatin-mediated maintenance of transcription [IMP]
- coronary artery morphogenesis [TAS]
- dorsal/ventral axis specification [IMP]
- dorsal/ventral pattern formation [IMP]
- ectoderm development [IMP]
- embryonic axis specification [IDA]
- embryonic digit morphogenesis [IGI, IMP]
- embryonic foregut morphogenesis [IMP]
- embryonic forelimb morphogenesis [IDA]
- embryonic heart tube development [IMP]
- embryonic hindlimb morphogenesis [IMP]
- embryonic skeletal limb joint morphogenesis [IGI]
- endoderm formation [IMP]
- endodermal cell fate commitment [IMP]
- epicardium-derived cardiac vascular smooth muscle cell differentiation [TAS]
- epithelial cell differentiation involved in prostate gland development [IMP]
- epithelial tube branching involved in lung morphogenesis [IMP]
- forebrain development [IMP]
- fungiform papilla formation [IMP]
- gastrulation with mouth forming second [IMP]
- genitalia morphogenesis [IMP]
- glial cell fate determination [IDA]
- hair cycle process [IMP]
- hair follicle morphogenesis [IMP]
- hair follicle placode formation [IGI, IMP]
- heart development [IMP]
- hemopoiesis [IDA]
- in utero embryonic development [IGI, IMP]
- kidney development [IMP]
- layer formation in cerebral cortex [IMP]
- lens morphogenesis in camera-type eye [IMP]
- limb development [IMP]
- lung cell differentiation [IMP]
- lung development [IMP]
- lung induction [IMP]
- lung-associated mesenchyme development [IMP]
- male genitalia development [IMP]
- mesenchymal cell proliferation involved in lung development [IMP]
- mesenchymal to epithelial transition involved in metanephros morphogenesis [IDA]
- mesenchyme development [TAS]
- mesenchyme morphogenesis [TAS]
- metanephros morphogenesis [IMP]
- morphogenesis of embryonic epithelium [IMP]
- negative regulation of apoptotic signaling pathway [IGI, IMP]
- negative regulation of cell differentiation [IMP]
- negative regulation of chondrocyte differentiation [IGI]
- negative regulation of mitotic cell cycle, embryonic [IMP]
- negative regulation of neuron death [IGI]
- negative regulation of oligodendrocyte differentiation [IMP]
- negative regulation of osteoclast differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- nephron tubule formation [IMP]
- neural plate development [IDA]
- neuron migration [IGI]
- odontogenesis of dentin-containing tooth [IMP]
- oocyte development [IGI]
- organ development [IMP]
- osteoclast differentiation [IMP]
- oviduct development [IMP]
- pancreas development [IMP]
- patterning of blood vessels [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of MAPK cascade [IGI]
- positive regulation of branching involved in lung morphogenesis [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of determination of dorsal identity [IDA]
- positive regulation of endothelial cell differentiation [IMP]
- positive regulation of epithelial cell differentiation [IMP]
- positive regulation of epithelial cell proliferation involved in prostate gland development [IMP]
- positive regulation of epithelial to mesenchymal transition [ISO, TAS]
- positive regulation of fibroblast growth factor receptor signaling pathway [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of neuroblast proliferation [IGI, IMP]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of telomerase activity [IMP]
- positive regulation of telomere maintenance via telomerase [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- proximal/distal pattern formation [IMP]
- regulation of T cell proliferation [IMP]
- regulation of apoptotic process [IMP]
- regulation of cell differentiation [IDA]
- regulation of cell fate specification [IBA]
- regulation of cell proliferation [IDA, IMP]
- regulation of centromeric sister chromatid cohesion [IMP]
- regulation of epithelial cell differentiation [IMP]
- regulation of gene expression [IMP]
- regulation of myelination [IMP]
- regulation of nephron tubule epithelial cell differentiation [IMP]
- regulation of osteoblast differentiation [IMP]
- regulation of osteoclast differentiation [IMP]
- regulation of secondary heart field cardioblast proliferation [IDA]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription, DNA-templated [IDA]
- renal inner medulla development [IMP]
- renal outer medulla development [IMP]
- renal system development [IMP]
- renal vesicle formation [IMP]
- single organismal cell-cell adhesion [IMP]
- skeletal system development [IMP]
- skin development [IMP]
- smooth muscle cell differentiation [IMP]
- stem cell maintenance [TAS]
- sympathetic ganglion development [IMP]
- synapse organization [IMP]
- synaptic transmission [IMP]
- synaptic vesicle transport [IMP]
- thymus development [IMP]
- trachea formation [IMP]
- trachea morphogenesis [IMP]
- vasculature development [IMP]
- vasculogenesis [IMP]
- ventricular compact myocardium morphogenesis [TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- alpha-catenin binding [IDA, IPI]
- cadherin binding [IPI, ISO]
- chromatin binding [IDA, IGI]
- double-stranded DNA binding [IDA]
- euchromatin binding [IDA]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- alpha-catenin binding [IDA, IPI]
- cadherin binding [IPI, ISO]
- chromatin binding [IDA, IGI]
- double-stranded DNA binding [IDA]
- euchromatin binding [IDA]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
- Scrib-APC-beta-catenin complex [IDA]
- Z disc [IDA]
- adherens junction [IDA]
- apical junction complex [IDA]
- apical part of cell [IDA]
- basolateral plasma membrane [IDA]
- beta-catenin destruction complex [IDA]
- catenin complex [IBA]
- catenin-TCF7L2 complex [IDA]
- cell [IMP]
- cell projection membrane [IDA]
- cell-cell adherens junction [IDA]
- cell-cell junction [IDA, ISO]
- centrosome [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- fascia adherens [IDA]
- intercalated disc [IDA]
- lamellipodium [IDA]
- lateral plasma membrane [IDA, ISO]
- membrane [IDA]
- microvillus membrane [IDA]
- nuclear euchromatin [IDA]
- nuclear transcription factor complex [IDA]
- nucleus [IDA]
- plasma membrane [IDA]
- protein complex [ISO]
- tight junction [IDA]
- transcription factor complex [IDA]
Mus musculus
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Pax3 functions at a nodal point in melanocyte stem cell differentiation.
Most stem cells are not totipotent. Instead, they are partially committed but remain undifferentiated. Upon appropriate stimulation they are capable of regenerating mature cell types. Little is known about the genetic programmes that maintain the undifferentiated phenotype of lineage-restricted stem cells. Here we describe the molecular details of a nodal point in adult melanocyte stem cell differentiation in which Pax3 ... [more]
Nature Feb. 24, 2005; 433(7028);884-7 [Pubmed: 15729346]
Throughput
- Low Throughput
Ontology Terms
- abnormal protein level (MP:0008469)
Additional Notes
- co-transfection of activated beta-catenin with Pax3 abolishes the repression of Sox10/Mitf activity by Pax3
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PAX3 CTNNB1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID