EHMT2
Gene Ontology Biological Process
- DNA methylation [IDA]
- DNA methylation on cytosine within a CG sequence [IMP]
- cellular response to drug [ISO]
- fertilization [IMP]
- germ cell development [IMP]
- histone H3-K27 methylation [IDA, IMP]
- histone H3-K9 methylation [IDA, IMP]
- histone lysine methylation [ISO]
- histone methylation [IMP, ISO]
- long-term memory [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- organ growth [IMP]
- peptidyl-lysine dimethylation [ISO]
- peptidyl-lysine methylation [IMP]
- regulation of DNA methylation [ISO]
- regulation of DNA replication [IMP, ISO]
- regulation of histone H3-K4 methylation [ISO]
- regulation of histone H3-K9 methylation [ISO]
- regulation of transcription from RNA polymerase II promoter [IMP]
- spermatid development [IMP]
- synaptonemal complex assembly [IMP]
Gene Ontology Molecular Function- C2H2 zinc finger domain binding [IPI, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- histone methyltransferase activity (H3-K27 specific) [IDA]
- histone methyltransferase activity (H3-K9 specific) [IDA, IMP]
- histone-lysine N-methyltransferase activity [IDA, IMP, ISO]
- p53 binding [ISO]
- protein binding [IPI]
- protein-lysine N-methyltransferase activity [ISO]
- C2H2 zinc finger domain binding [IPI, ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- histone methyltransferase activity (H3-K27 specific) [IDA]
- histone methyltransferase activity (H3-K9 specific) [IDA, IMP]
- histone-lysine N-methyltransferase activity [IDA, IMP, ISO]
- p53 binding [ISO]
- protein binding [IPI]
- protein-lysine N-methyltransferase activity [ISO]
Gene Ontology Cellular Component
H3F3A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Methylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Functional analysis of the N- and C-terminus of mammalian G9a histone H3 methyltransferase.
Methylation of lysine 9 (K9) in the N-terminus tail of histone H3 (H3) in chromatin is associated with transcriptionally silenced genes and is mediated by histone methyltransferases. Murine G9a is a 1263 amino acid H3-K9 methyltransferase that possesses characteristic SET domain and ANK repeats. In this paper, we have used a series of green fluorescent protein-tagged deletion constructs to identify ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID