GATA1
Gene Ontology Biological Process
- cell development [IMP]
- cell-cell signaling [IMP]
- cellular response to thyroid hormone stimulus [ISO]
- dendritic cell differentiation [IDA]
- embryonic hemopoiesis [IMP]
- eosinophil fate commitment [ISO]
- erythrocyte development [ISO]
- erythrocyte differentiation [IDA, IGI, IMP]
- in utero embryonic development [IMP]
- male gonad development [ISO]
- megakaryocyte differentiation [IDA, IGI, IMP, ISO]
- myeloid cell differentiation [IMP]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of bone mineralization [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- negative regulation of transcription regulatory region DNA binding [ISO]
- platelet aggregation [IMP, ISO]
- platelet formation [IMP, ISO]
- positive regulation of erythrocyte differentiation [ISO]
- positive regulation of osteoblast proliferation [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- regulation of definitive erythrocyte differentiation [IDA, ISO]
- regulation of glycoprotein biosynthetic process [IMP, ISO]
- transcription from RNA polymerase II promoter [IDA, ISO]
- transcriptional activation by promoter-enhancer looping [IDA]
Gene Ontology Molecular Function- C2H2 zinc finger domain binding [ISO]
- DNA binding [IDA, ISO]
- DNA binding, bending [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription factor binding [IPI, ISO]
- chromatin DNA binding [ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [IDA]
- p53 binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription regulatory region sequence-specific DNA binding [ISO]
- C2H2 zinc finger domain binding [ISO]
- DNA binding [IDA, ISO]
- DNA binding, bending [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription factor binding [IPI, ISO]
- chromatin DNA binding [ISO]
- chromatin binding [IDA]
- enhancer sequence-specific DNA binding [IDA]
- p53 binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription regulatory region sequence-specific DNA binding [ISO]
Gene Ontology Cellular Component
ZFPM1
Gene Ontology Biological Process
- atrial septum morphogenesis [IMP]
- atrioventricular valve morphogenesis [IMP]
- cardiac muscle tissue morphogenesis [IMP]
- definitive erythrocyte differentiation [IMP]
- embryonic hemopoiesis [IMP]
- erythrocyte differentiation [IGI, IMP]
- granulocyte differentiation [IMP]
- heart development [IMP]
- homeostasis of number of cells [IMP]
- megakaryocyte development [IMP]
- megakaryocyte differentiation [IGI, IMP]
- mitral valve formation [IMP]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of interleukin-4 biosynthetic process [ISO]
- negative regulation of mast cell differentiation [IDA]
- negative regulation of protein binding [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IBA, IDA, IMP, ISO, TAS]
- outflow tract morphogenesis [IMP]
- platelet formation [ISO]
- positive regulation of interferon-gamma biosynthetic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- primitive erythrocyte differentiation [IMP]
- regulation of chemokine production [IMP]
- regulation of definitive erythrocyte differentiation [ISO]
- transcription from RNA polymerase II promoter [IBA]
- transcriptional activation by promoter-enhancer looping [IDA]
- tricuspid valve formation [IMP]
- ventricular septum morphogenesis [IMP]
Gene Ontology Molecular Function- RNA polymerase II activating transcription factor binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IBA, ISO]
- RNA polymerase II transcription factor binding [ISO]
- protein binding [IPI]
- transcription corepressor activity [TAS]
- transcription factor binding [ISO]
- RNA polymerase II activating transcription factor binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IBA, ISO]
- RNA polymerase II transcription factor binding [ISO]
- protein binding [IPI]
- transcription corepressor activity [TAS]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
GATA-1 forms distinct activating and repressive complexes in erythroid cells.
GATA-1 is essential for the generation of the erythroid, megakaryocytic, eosinophilic and mast cell lineages. It acts as an activator and repressor of different target genes, for example, in erythroid cells it represses cell proliferation and early hematopoietic genes while activating erythroid genes, yet it is not clear how both of these functions are mediated. Using a biotinylation tagging/proteomics approach ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ZFPM1 GATA1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| ZFPM1 GATA1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID