KLF6
Gene Ontology Biological Process
Gene Ontology Molecular Function
HDAC3
Gene Ontology Biological Process
- cellular response to fluid shear stress [ISO]
- chromatin modification [TAS]
- circadian regulation of gene expression [IGI]
- histone deacetylation [IGI, IMP, ISO]
- negative regulation of JNK cascade [ISO]
- negative regulation of cardiac muscle cell differentiation [IMP]
- negative regulation of interleukin-1 production [ISO]
- negative regulation of protein export from nucleus [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of tumor necrosis factor production [ISO]
- positive regulation of TOR signaling [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of type B pancreatic cell apoptotic process [ISO]
- protein deacetylation [IDA, ISO]
- regulation of mitotic cell cycle [IDA]
- regulation of multicellular organism growth [IGI]
- regulation of protein stability [ISO]
- spindle assembly [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- GTPase binding [ISO]
- chromatin DNA binding [IDA]
- chromatin binding [IDA, ISO]
- cyclin binding [ISO]
- enzyme binding [ISO]
- histone deacetylase activity [ISO, TAS]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IDA, ISO, TAS]
- DNA binding [IDA]
- GTPase binding [ISO]
- chromatin DNA binding [IDA]
- chromatin binding [IDA, ISO]
- cyclin binding [ISO]
- enzyme binding [ISO]
- histone deacetylase activity [ISO, TAS]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IDA, ISO, TAS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Krueppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1.
Preadipocyte differentiation occurs during distinct periods of human development and is a key determinant of body mass. Transcriptional events underlying adipogenesis continue to emerge, but the link between chromatin remodeling of specific target loci and preadipocyte differentiation remains elusive. We have identified Krueppel-like factor-6 (KLF6), a recently described tumor suppressor gene, as a repressor of the proto-oncogene Delta-like 1 (Dlk1), ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HDAC3 KLF6 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID