STAT3
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, ISS, TAS]
- astrocyte differentiation [ISS]
- cellular component movement [TAS]
- cellular response to hormone stimulus [IDA]
- cytokine-mediated signaling pathway [NAS]
- eating behavior [ISS]
- eye photoreceptor cell differentiation [ISS]
- glucose homeostasis [ISS]
- growth hormone receptor signaling pathway [IDA]
- interleukin-6-mediated signaling pathway [IDA]
- intracellular receptor signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- nervous system development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphorylation [ISS]
- positive regulation of Notch signaling pathway [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- protein import into nucleus [IDA]
- radial glial cell differentiation [ISS]
- regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of transcription, DNA-templated [IDA]
- response to estradiol [IDA]
- sexual reproduction [ISS]
- signal transduction [TAS]
- temperature homeostasis [ISS]
Gene Ontology Molecular Function- DNA binding [ISS]
- RNA polymerase II repressing transcription factor binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein dimerization activity [ISS]
- protein kinase binding [ISS]
- protein phosphatase binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [ISS]
- RNA polymerase II repressing transcription factor binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein dimerization activity [ISS]
- protein kinase binding [ISS]
- protein phosphatase binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
DNMT1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.
Expression of SHP-1 phosphatase, a key negative regulator of cell signaling, is lost in T cell lymphomas and other malignancies due to DNA methylation of the SHP-1 promoter by a currently undefined mechanism. We demonstrate that malignant T cells express DNA methyltransferase (DNMT) 1 and that constantly activated signal transducer and activator of transcription (STAT) 3 is capable of binding ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DNMT1 STAT3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 1513449 | |
| DNMT1 STAT3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| STAT3 DNMT1 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 503438 |
Curated By
- BioGRID