SIAH1
Gene Ontology Biological Process
- male meiosis I [ISO]
- neuron apoptotic process [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- post-embryonic development [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO, ISS]
- protein catabolic process [ISO]
- protein destabilization [IMP]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA, ISO, ISS]
- regulation of multicellular organism growth [ISO]
- spermatogenesis [ISO]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SNCAIP
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Siah-1 facilitates ubiquitination and degradation of synphilin-1.
Parkinson's disease is a common neurodegenerative disorder characterized by loss of dopaminergic neurons and appearance of Lewy bodies, cytoplasmic inclusions that are highly enriched with ubiquitin. Synphilin-1, alpha-synuclein, and Parkin represent the major components of Lewy bodies and are involved in the pathogenesis of Parkinson's disease. Synphilin-1 is an alpha-synuclein-binding protein that is ubiquitinated by Parkin. Recently, a mutation in ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID