AXIN1
Gene Ontology Biological Process
- Wnt signaling pathway [IDA, IPI, ISO]
- Wnt signaling pathway involved in somitogenesis [IBA]
- Wnt-activated signaling pathway involved in forebrain neuron fate commitment [IBA]
- activation of JUN kinase activity [IBA]
- activation of protein kinase activity [ISO]
- adult walking behavior [IMP]
- axial mesoderm development [IMP]
- axial mesoderm formation [IMP]
- canonical Wnt signaling pathway [IDA, IMP]
- canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation [IBA]
- cell death [IBA]
- cellular protein complex assembly [ISO]
- cellular response to organic cyclic compound [IBA]
- cytoplasmic microtubule organization [IGI]
- determination of left/right symmetry [IBA]
- dorsal/ventral axis specification [IDA, ISO]
- dorsal/ventral pattern formation [IMP, ISO]
- embryonic eye morphogenesis [IBA]
- embryonic skeletal joint morphogenesis [IMP]
- erythrocyte homeostasis [IMP]
- forebrain anterior/posterior pattern specification [IBA]
- genetic imprinting [IMP]
- hemoglobin metabolic process [IMP]
- in utero embryonic development [IGI, IMP]
- muscle cell development [IBA]
- negative regulation of Wnt signaling pathway [IDA, ISO]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of fat cell differentiation [IDA]
- negative regulation of protein metabolic process [IDA]
- negative regulation of transcription elongation from RNA polymerase II promoter [IDA]
- neurological system process [IMP]
- nucleocytoplasmic transport [IDA]
- olfactory placode formation [IBA]
- optic placode formation [IBA]
- positive regulation of GTPase activity [IBA]
- positive regulation of JNK cascade [IMP]
- positive regulation of JUN kinase activity [IDA, IMP, ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein phosphorylation [IDA, ISO]
- positive regulation of protein ubiquitination [IDA, IGI, IMP]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA, IGI, IMP]
- positive regulation of ubiquitin-protein transferase activity [IMP, ISO]
- post-anal tail morphogenesis [IMP]
- protein catabolic process [IDA]
- protein homooligomerization [IDA, ISO]
- protein polyubiquitination [IDA]
- regulation of catenin import into nucleus [IDA]
- regulation of protein phosphorylation [IGI]
- sensory perception of sound [IMP]
Gene Ontology Molecular Function- GTPase activator activity [IBA]
- I-SMAD binding [IDA, IPI, ISO]
- R-SMAD binding [IPI]
- SMAD binding [ISO]
- armadillo repeat domain binding [IBA, ISO]
- beta-catenin binding [IMP, IPI, ISO]
- enzyme binding [ISO]
- identical protein binding [IPI, ISO]
- p53 binding [IPI]
- protein C-terminus binding [IDA, IPI]
- protein binding [IPI]
- protein complex scaffold [IMP, ISO]
- protein domain specific binding [IPI, ISO]
- protein homodimerization activity [IPI]
- protein kinase binding [IPI, ISO]
- protein self-association [IPI]
- receptor binding [ISO]
- signal transducer activity [ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- GTPase activator activity [IBA]
- I-SMAD binding [IDA, IPI, ISO]
- R-SMAD binding [IPI]
- SMAD binding [ISO]
- armadillo repeat domain binding [IBA, ISO]
- beta-catenin binding [IMP, IPI, ISO]
- enzyme binding [ISO]
- identical protein binding [IPI, ISO]
- p53 binding [IPI]
- protein C-terminus binding [IDA, IPI]
- protein binding [IPI]
- protein complex scaffold [IMP, ISO]
- protein domain specific binding [IPI, ISO]
- protein homodimerization activity [IPI]
- protein kinase binding [IPI, ISO]
- protein self-association [IPI]
- receptor binding [ISO]
- signal transducer activity [ISO]
- ubiquitin protein ligase binding [IPI, ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- beta-catenin destruction complex [IDA, ISO]
- cell cortex [IDA]
- cell periphery [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytoplasmic microtubule [IDA]
- cytoplasmic vesicle [ISO]
- lateral plasma membrane [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IBA, ISO]
- protein complex [IDA]
CTNNB1
Gene Ontology Biological Process
- T cell differentiation [IMP]
- T cell differentiation in thymus [IMP]
- Wnt signaling pathway [IDA]
- adherens junction organization [IMP]
- anterior/posterior axis specification [IMP]
- bone resorption [IGI, IMP]
- branching involved in ureteric bud morphogenesis [IMP]
- canonical Wnt signaling pathway [IDA, IGI, IMP]
- canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation [IMP]
- cardiac muscle cell proliferation [TAS]
- cardiac vascular smooth muscle cell differentiation [TAS]
- cell differentiation [IMP]
- cell fate determination [IMP]
- cell fate specification [IMP]
- cell maturation [IDA, IMP]
- cell morphogenesis involved in differentiation [IMP]
- cell proliferation [IMP]
- cell-matrix adhesion [IMP]
- cellular process [IDA]
- cellular protein localization [IMP]
- cellular response to organic cyclic compound [IDA]
- central nervous system vasculogenesis [IMP]
- chromatin-mediated maintenance of transcription [IMP]
- coronary artery morphogenesis [TAS]
- dorsal/ventral axis specification [IMP]
- dorsal/ventral pattern formation [IMP]
- ectoderm development [IMP]
- embryonic axis specification [IDA]
- embryonic digit morphogenesis [IGI, IMP]
- embryonic foregut morphogenesis [IMP]
- embryonic forelimb morphogenesis [IDA]
- embryonic heart tube development [IMP]
- embryonic hindlimb morphogenesis [IMP]
- embryonic skeletal limb joint morphogenesis [IGI]
- endoderm formation [IMP]
- endodermal cell fate commitment [IMP]
- epicardium-derived cardiac vascular smooth muscle cell differentiation [TAS]
- epithelial cell differentiation involved in prostate gland development [IMP]
- epithelial tube branching involved in lung morphogenesis [IMP]
- forebrain development [IMP]
- fungiform papilla formation [IMP]
- gastrulation with mouth forming second [IMP]
- genitalia morphogenesis [IMP]
- glial cell fate determination [IDA]
- hair cycle process [IMP]
- hair follicle morphogenesis [IMP]
- hair follicle placode formation [IGI, IMP]
- heart development [IMP]
- hemopoiesis [IDA]
- in utero embryonic development [IGI, IMP]
- kidney development [IMP]
- layer formation in cerebral cortex [IMP]
- lens morphogenesis in camera-type eye [IMP]
- limb development [IMP]
- lung cell differentiation [IMP]
- lung development [IMP]
- lung induction [IMP]
- lung-associated mesenchyme development [IMP]
- male genitalia development [IMP]
- mesenchymal cell proliferation involved in lung development [IMP]
- mesenchymal to epithelial transition involved in metanephros morphogenesis [IDA]
- mesenchyme development [TAS]
- mesenchyme morphogenesis [TAS]
- metanephros morphogenesis [IMP]
- morphogenesis of embryonic epithelium [IMP]
- negative regulation of apoptotic signaling pathway [IGI, IMP]
- negative regulation of cell differentiation [IMP]
- negative regulation of chondrocyte differentiation [IGI]
- negative regulation of mitotic cell cycle, embryonic [IMP]
- negative regulation of neuron death [IGI]
- negative regulation of oligodendrocyte differentiation [IMP]
- negative regulation of osteoclast differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- nephron tubule formation [IMP]
- neural plate development [IDA]
- neuron migration [IGI]
- odontogenesis of dentin-containing tooth [IMP]
- oocyte development [IGI]
- organ development [IMP]
- osteoclast differentiation [IMP]
- oviduct development [IMP]
- pancreas development [IMP]
- patterning of blood vessels [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of MAPK cascade [IGI]
- positive regulation of branching involved in lung morphogenesis [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of determination of dorsal identity [IDA]
- positive regulation of endothelial cell differentiation [IMP]
- positive regulation of epithelial cell differentiation [IMP]
- positive regulation of epithelial cell proliferation involved in prostate gland development [IMP]
- positive regulation of epithelial to mesenchymal transition [ISO, TAS]
- positive regulation of fibroblast growth factor receptor signaling pathway [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of neuroblast proliferation [IGI, IMP]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of telomerase activity [IMP]
- positive regulation of telomere maintenance via telomerase [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- proximal/distal pattern formation [IMP]
- regulation of T cell proliferation [IMP]
- regulation of apoptotic process [IMP]
- regulation of cell differentiation [IDA]
- regulation of cell fate specification [IBA]
- regulation of cell proliferation [IDA, IMP]
- regulation of centromeric sister chromatid cohesion [IMP]
- regulation of epithelial cell differentiation [IMP]
- regulation of gene expression [IMP]
- regulation of myelination [IMP]
- regulation of nephron tubule epithelial cell differentiation [IMP]
- regulation of osteoblast differentiation [IMP]
- regulation of osteoclast differentiation [IMP]
- regulation of secondary heart field cardioblast proliferation [IDA]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription, DNA-templated [IDA]
- renal inner medulla development [IMP]
- renal outer medulla development [IMP]
- renal system development [IMP]
- renal vesicle formation [IMP]
- single organismal cell-cell adhesion [IMP]
- skeletal system development [IMP]
- skin development [IMP]
- smooth muscle cell differentiation [IMP]
- stem cell maintenance [TAS]
- sympathetic ganglion development [IMP]
- synapse organization [IMP]
- synaptic transmission [IMP]
- synaptic vesicle transport [IMP]
- thymus development [IMP]
- trachea formation [IMP]
- trachea morphogenesis [IMP]
- vasculature development [IMP]
- vasculogenesis [IMP]
- ventricular compact myocardium morphogenesis [TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- alpha-catenin binding [IDA, IPI]
- cadherin binding [IPI, ISO]
- chromatin binding [IDA, IGI]
- double-stranded DNA binding [IDA]
- euchromatin binding [IDA]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [IDA]
- alpha-catenin binding [IDA, IPI]
- cadherin binding [IPI, ISO]
- chromatin binding [IDA, IGI]
- double-stranded DNA binding [IDA]
- euchromatin binding [IDA]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
- Scrib-APC-beta-catenin complex [IDA]
- Z disc [IDA]
- adherens junction [IDA]
- apical junction complex [IDA]
- apical part of cell [IDA]
- basolateral plasma membrane [IDA]
- beta-catenin destruction complex [IDA]
- catenin complex [IBA]
- catenin-TCF7L2 complex [IDA]
- cell [IMP]
- cell projection membrane [IDA]
- cell-cell adherens junction [IDA]
- cell-cell junction [IDA, ISO]
- centrosome [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- fascia adherens [IDA]
- intercalated disc [IDA]
- lamellipodium [IDA]
- lateral plasma membrane [IDA, ISO]
- membrane [IDA]
- microvillus membrane [IDA]
- nuclear euchromatin [IDA]
- nuclear transcription factor complex [IDA]
- nucleus [IDA]
- plasma membrane [IDA]
- protein complex [ISO]
- tight junction [IDA]
- transcription factor complex [IDA]
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Both the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesis.
Axin is a negative regulator of canonical Wnt signaling, which promotes the degradation of beta-catenin, the major effector in this signaling cascade. While many protein-binding domains of Axin have been identified, their significance has not been evaluated in vivo. Here, we report the generation and analysis of mice carrying modified Axin alleles in which either the RGS domain or the ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: embryonic lethality (MP:0008762)
Additional Notes
- Heterozygosity for beta-catenin completely rescues the embryonic lethality of an Axin mutant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AXIN1 CTNNB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| AXIN1 CTNNB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| AXIN1 CTNNB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| AXIN1 CTNNB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CTNNB1 AXIN1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID