Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation.

Ramel MC, Buckles GR, Baker KD, Lekven AC

During vertebrate mesoderm formation, fates are established according to position in the dorsoventral (D/V) axis of the embryo. Initially, maternal signaling divides nascent mesoderm into axial (dorsal) and non-axial (ventral) domains. Although the subsequent subdivision of non-axial mesoderm into multiple D/V fate domains is known to involve zygotic Wnt8 and BMP signaling as well as the Vent/Vox/Ved family of transcriptional ... [more]

Dev. Biol. Nov. 15, 2005; 287(2);237-48 [Pubmed: 16216234]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: axis (ZFA:0000092) [malformed (PATO:0000646)|dorsal-ventral polarity (PATO:0001775)]
  • phenotype: mesoderm (ZFA:0000041) [malformed (PATO:0000646)]

Additional Notes

  • vent; vox; ved triple loss-of-function mutant (Df(LG13:vox,vent)st7/st7, MO:wnt8a)

Curated By

  • BioGRID