RRN3
Gene Ontology Biological Process
- DNA-templated transcription, initiation [IDA]
- cell proliferation [IMP]
- cytoplasm organization [IMP]
- homeostasis of number of cells [IMP]
- in utero embryonic development [IMP]
- negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [IMP]
- nucleolus organization [IMP]
- positive regulation of neuron projection development [ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of DNA-templated transcription, initiation [IDA]
- ribosome biogenesis [IMP]
- transcription initiation from RNA polymerase I promoter [IMP]
Gene Ontology Molecular Function
POLR1B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis.
Cells respond to a variety of extracellular and intracellular forms of stress by down-regulating rRNA synthesis. We have investigated the mechanism underlying stress-dependent inhibition of RNA polymerase I (Pol I) transcription and show that the Pol I-specific transcription factor TIF-IA is inactivated upon stress. Inactivation is due to phosphorylation of TIF-IA by c-Jun N-terminal kinase (JNK) at a single threonine ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID