IFRD1
Gene Ontology Biological Process
- muscle cell differentiation [IMP]
- negative regulation of axon extension [IGI]
- negative regulation of collateral sprouting [IGI]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- skeletal muscle tissue regeneration [IMP]
- striated muscle tissue development [IMP]
Gene Ontology Molecular Function
HDAC4
Gene Ontology Biological Process
- chromatin remodeling [ISO]
- histone H3 deacetylation [ISO]
- histone H4 deacetylation [ISO]
- histone deacetylation [ISO]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of glycolytic process [IMP]
- negative regulation of myotube differentiation [ISO]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP, ISO]
- osteoblast development [IMP]
- peptidyl-lysine deacetylation [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein sumoylation [ISO]
- positive regulation of reactive oxygen species biosynthetic process [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- positive regulation of transcription, DNA-templated [IMP]
- protein deacetylation [IDA]
- regulation of cardiac muscle contraction by calcium ion signaling [IMP]
- regulation of gene expression, epigenetic [ISO]
- regulation of protein binding [ISO]
- regulation of skeletal muscle fiber development [IGI]
- regulation of striated muscle cell differentiation [IGI]
- response to denervation involved in regulation of muscle adaptation [IMP]
- response to drug [ISO]
- response to interleukin-1 [ISO]
- skeletal system development [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- activating transcription factor binding [ISO]
- core promoter binding [ISO]
- histone deacetylase activity [ISO]
- histone deacetylase binding [ISO]
- potassium ion binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, ISO]
- protein kinase binding [IPI]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [ISO]
- transcription corepressor activity [IGI]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- zinc ion binding [ISO]
- DNA binding [IDA]
- activating transcription factor binding [ISO]
- core promoter binding [ISO]
- histone deacetylase activity [ISO]
- histone deacetylase binding [ISO]
- potassium ion binding [ISO]
- protein binding [IPI]
- protein deacetylase activity [IDA, ISO]
- protein kinase binding [IPI]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [ISO]
- transcription corepressor activity [IGI]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
PC4 coactivates MyoD by relieving the histone deacetylase 4-mediated inhibition of myocyte enhancer factor 2C.
Histone deacetylase 4 (HDAC4) negatively regulates skeletal myogenesis by associating with the myocyte enhancer factor 2 (MEF2) transcription factors. Our data indicate that the gene PC4 (interferon-related developmental regulator 1 [IFRD1], Tis7), which we have previously shown to be required for myoblast differentiation, is both induced by MyoD and potentiates the transcriptional activity of MyoD, thus revealing a positive regulatory ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HDAC4 IFRD1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID