BAIT
PURA
CAGER-1, Pur-alpha, ssCRE-BP
purine rich element binding protein A
GO Process (9)
GO Function (11)
GO Component (5)
Gene Ontology Biological Process
- DNA unwinding involved in DNA replication [ISO]
- apoptotic process [NAS]
- cell differentiation [NAS]
- cell proliferation [NAS]
- mitotic cell cycle checkpoint [NAS]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of translation [IDA]
- nervous system development [IMP]
- positive regulation of cell proliferation [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- SMAD binding [IDA]
- double-stranded DNA binding [IDA]
- double-stranded telomeric DNA binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- purine-rich negative regulatory element binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- single-stranded DNA binding [IDA]
- transcription factor binding [IPI]
- translation repressor activity, nucleic acid binding [IDA]
- DNA binding [IDA]
- SMAD binding [IDA]
- double-stranded DNA binding [IDA]
- double-stranded telomeric DNA binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- purine-rich negative regulatory element binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- single-stranded DNA binding [IDA]
- transcription factor binding [IPI]
- translation repressor activity, nucleic acid binding [IDA]
Mus musculus
PREY
CCNB1
Ccnb1-rs1, Ccnb1-rs13, CycB1, Cycb-4, Cycb-5, Cycb1-rs1
cyclin B1
GO Process (19)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
- histone H3-S10 phosphorylation involved in chromosome condensation [IDA]
- histone phosphorylation [ISO]
- in utero embryonic development [IMP]
- mitotic metaphase plate congression [ISO]
- mitotic spindle stabilization [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of protein phosphorylation [ISO]
- oocyte maturation [ISO]
- positive regulation of attachment of spindle microtubules to kinetochore [ISO]
- positive regulation of cardiac muscle cell proliferation [ISO]
- positive regulation of cell cycle [IDA]
- positive regulation of fibroblast proliferation [IMP]
- positive regulation of histone phosphorylation [ISO]
- positive regulation of mRNA 3'-end processing [ISO]
- positive regulation of mitotic cell cycle [ISO]
- protein complex assembly [ISO]
- protein phosphorylation [IDA]
- regulation of chromosome condensation [ISO]
- regulation of mitotic cell cycle spindle assembly checkpoint [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Functional interaction of Puralpha with the Cdk2 moiety of cyclin A/Cdk2.
Puralpha is a sequence-specific single-stranded nucleic acid-binding protein and a member of the highly conserved Pur family. Puralpha has been shown to colocalize with cyclin A/Cdk2 and to coimmunoprecipitate with cyclin A during S-phase. Here we show that this interaction is mediated by a specific affinity of Puralpha for Cdk2. In pull-down assays GST-Puralpha efficiently binds Cdk2 and Cdk1, binds ... [more]
Biochem. Biophys. Res. Commun. Mar. 25, 2005; 328(4);851-7 [Pubmed: 15707957]
Throughput
- Low Throughput
Curated By
- BioGRID