PARP10
Gene Ontology Biological Process
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of fibroblast proliferation [IDA]
- negative regulation of gene expression [IMP]
- negative regulation of protein K63-linked ubiquitination [IMP]
- negative regulation of protein import into nucleus, translocation [IMP]
- negative regulation of viral genome replication [IMP]
- protein ADP-ribosylation [IMP]
- protein auto-ADP-ribosylation [IMP]
- protein poly-ADP-ribosylation [IDA]
- regulation of chromatin assembly [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HIST2H2BE
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Ribosylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation.
The proto-oncoprotein c-Myc functions as a transcriptional regulator that controls different aspects of cell behavior, including proliferation, differentiation, and apoptosis. In addition, Myc proteins have the potential to transform cells and are deregulated in the majority of human cancers. Several Myc-interacting factors have been described that mediate part of Myc's functions in the control of cell behavior. Here, we describe ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID