BAIT
WNT11
wingless-type MMTV integration site family, member 11
GO Process (35)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- artery morphogenesis [IMP]
- bone mineralization [IGI]
- canonical Wnt signaling pathway [IDA]
- cell fate commitment [IBA]
- cell-cell signaling [TAS]
- kidney development [IDA]
- negative regulation of apoptotic process [ISO]
- negative regulation of canonical Wnt signaling pathway [IDA, ISO]
- negative regulation of cell death [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of fibroblast growth factor production [IMP]
- negative regulation of mesenchymal cell proliferation [IMP]
- negative regulation of transcription, DNA-templated [ISO]
- neuroendocrine cell differentiation [ISO]
- neuron differentiation [IBA]
- non-canonical Wnt signaling pathway [IMP]
- organ morphogenesis [TAS]
- osteoblast differentiation [IGI]
- outflow tract morphogenesis [IMP]
- palate development [IMP, ISO]
- positive regulation of Ras GTPase activity [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of cell migration [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of protein kinase C signaling [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of transforming growth factor beta2 production [IMP]
- protein localization to cell surface [ISO]
- protein phosphorylation [ISO]
- signal transduction [TAS]
- tight junction assembly [IMP]
- ventricular septum morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TCF4
5730422P05Rik, ASP-I2, E2-2, E2.2, ITF-2, ITF-2b, ITF2, ME2, MITF-2A, MITF-2B, SEF-2, SEF2, SEF2-1, TFE, Tcf-4, bHLHb19
transcription factor 4
GO Process (8)
GO Function (15)
GO Component (2)
Gene Ontology Biological Process
- DNA-templated transcription, initiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of neuron differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein-DNA complex assembly [IDA]
- regulation of transcription, DNA-templated [IDA]
- transcription initiation from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- TFIIB-class binding transcription factor activity [IDA]
- TFIIB-class transcription factor binding [IDA]
- bHLH transcription factor binding [ISO]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding RNA polymerase recruiting transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription corepressor activity [IDA]
- DNA binding [IDA, ISO]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- TFIIB-class binding transcription factor activity [IDA]
- TFIIB-class transcription factor binding [IDA]
- bHLH transcription factor binding [ISO]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding RNA polymerase recruiting transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription corepressor activity [IDA]
Gene Ontology Cellular Component
Mus musculus
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2.
Wnt11 signals through both canonical (beta-catenin) and non-canonical pathways and is up-regulated during osteoblast differentiation and fracture healing. In these studies, we evaluated the role of Wnt11 during osteoblastogenesis. Wnt11 overexpression in MC3T3E1 pre-osteoblasts increases beta-catenin accumulation and promotes bone morphogenetic protein (BMP)-induced expression of alkaline phosphatase and mineralization. Wnt11 dramatically increases expression of the osteoblast-associated genes Dmp1 (dentin matrix ... [more]
J. Biol. Chem. May. 22, 2009; 284(21);14117-25 [Pubmed: 19213727]
Throughput
- Low Throughput
Ontology Terms
- phenotype: abnormal bone mineralization (MP:0002896)
- phenotype: abnormal protein level (MP:0008469)
Additional Notes
- expression of a dominant negative tcf4 blocks the effects of wnt11 overexpression, including expression of specific genes and mineralization
Curated By
- BioGRID