BAIT
DKK1
mdkk-1
dickkopf homolog 1 (Xenopus laevis)
GO Process (28)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- Wnt signaling pathway involved in somitogenesis [IGI]
- cell morphogenesis involved in differentiation [IMP]
- embryonic limb morphogenesis [IGI]
- endoderm development [IMP]
- endoderm formation [IDA]
- extracellular negative regulation of signal transduction [ISO]
- face morphogenesis [IMP]
- forebrain development [IGI]
- hair follicle development [IDA]
- head morphogenesis [IGI]
- mesoderm formation [IDA]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of Wnt signaling pathway [IDA, ISO]
- negative regulation of canonical Wnt signaling pathway [IDA, IGI, IMP, ISO]
- negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [ISO]
- negative regulation of cardiac muscle cell differentiation [ISO]
- negative regulation of mesodermal cell fate specification [ISO]
- negative regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- negative regulation of peptidyl-serine phosphorylation [ISO]
- negative regulation of protein complex assembly [ISO]
- negative regulation of receptor activity [ISO]
- negative regulation of skeletal muscle tissue development [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway [IDA]
- regulation of Wnt signaling pathway [IMP]
- regulation of endodermal cell fate specification [ISO]
- regulation of receptor internalization [ISO]
- response to retinoic acid [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
WNT3
Int-4, Wnt-3, RP23-326K2.2
wingless-type MMTV integration site family, member 3
GO Process (23)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- Spemann organizer formation at the anterior end of the primitive streak [IMP]
- anatomical structure formation involved in morphogenesis [IMP]
- anterior/posterior axis specification [IMP]
- anterior/posterior pattern specification [IMP]
- axon guidance [IDA]
- canonical Wnt signaling pathway [IGI, ISO]
- canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation [ISO]
- canonical Wnt signaling pathway involved in osteoblast differentiation [ISO]
- cell morphogenesis [ISO]
- cell-cell signaling [TAS]
- dorsal/ventral axis specification [IMP]
- embryonic forelimb morphogenesis [IMP]
- embryonic hindlimb morphogenesis [IMP]
- gamete generation [IGI]
- head morphogenesis [IGI]
- limb bud formation [ISO]
- limb development [IMP]
- mesoderm formation [IMP]
- negative regulation of axon extension involved in axon guidance [IDA]
- organ morphogenesis [TAS]
- positive regulation of collateral sprouting in absence of injury [IDA]
- positive regulation of gene expression [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Dkk1 and Wnt3 interact to control head morphogenesis in the mouse.
Loss of Dkk1 results in ectopic WNT/beta-catenin signalling activity in the anterior germ layer tissues and impairs cell movement in the endoderm of the mouse gastrula. The juxtaposition of the expression domains of Dkk1 and Wnt3 is suggestive of an antagonist-agonist interaction. The downregulation of Dkk1 when Wnt3 activity is reduced reveals a feedback mechanism for regulating WNT signalling. Compound ... [more]
Development May. 01, 2008; 135(10);1791-801 [Pubmed: 18403408]
Throughput
- Low Throughput
Ontology Terms
- phenotype: abnormal head morphology (MP:0000432)
- phenotype: abnormal embryogenesis/ development (MP:0001672)
Additional Notes
- decreasing endogenousevels of wnt3 partially supresses the defects seen upon loss of Dkk1
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| WNT3 DKK1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 504787 |
Curated By
- BioGRID