BAIT
WNT1
Int-1, Wnt-1, sw, swaying
wingless-type MMTV integration site family, member 1
GO Process (49)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- Spemann organizer formation [IMP]
- T cell differentiation in thymus [IDA]
- Wnt signaling pathway [IDA, ISO]
- bone development [ISO]
- branching involved in ureteric bud morphogenesis [IGI]
- canonical Wnt signaling pathway [IDA, IGI, ISO]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [ISO]
- cell-cell signaling [IDA, TAS]
- central nervous system morphogenesis [IMP]
- cerebellum formation [IMP]
- diencephalon development [IGI]
- embryonic axis specification [IMP]
- forebrain anterior/posterior pattern specification [IGI]
- hematopoietic stem cell proliferation [IDA]
- hepatocyte differentiation [ISO]
- inner ear morphogenesis [IGI]
- metencephalon development [IMP]
- midbrain development [IMP]
- midbrain-hindbrain boundary development [IMP]
- midbrain-hindbrain boundary maturation during brain development [IMP]
- myoblast fusion [IDA, IGI]
- myotube differentiation [IGI]
- negative regulation of BMP signaling pathway [ISO]
- negative regulation of cell aging [ISO]
- negative regulation of cell differentiation [IMP]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of cell-substrate adhesion [ISO]
- negative regulation of fat cell differentiation [IDA, IMP]
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA]
- neuron fate commitment [IMP]
- neuron fate determination [IMP]
- organ morphogenesis [TAS]
- organ regeneration [ISO]
- positive regulation of Notch signaling pathway [ISO]
- positive regulation of cell proliferation [IDA, ISO]
- positive regulation of dermatome development [ISO]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of insulin-like growth factor receptor signaling pathway [ISO]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- signal transduction [TAS]
- signal transduction in response to DNA damage [ISO]
- spinal cord association neuron differentiation [IGI]
- ubiquitin-dependent SMAD protein catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
FZD1
AW227548, FZ-1, Fz1
frizzled homolog 1 (Drosophila)
GO Process (22)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IBA]
- Wnt signaling pathway [IGI, ISO]
- autocrine signaling [ISO]
- canonical Wnt signaling pathway [IMP, ISO]
- canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation [ISO]
- canonical Wnt signaling pathway involved in osteoblast differentiation [ISO]
- cell-cell signaling [IDA, ISO]
- epithelial cell differentiation [IDA, IGI]
- hard palate development [IGI]
- membranous septum morphogenesis [IGI]
- muscular septum morphogenesis [IGI]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of catenin import into nucleus [IDA]
- negative regulation of transcription, DNA-templated [IMP]
- outflow tract morphogenesis [IGI]
- planar cell polarity pathway involved in neural tube closure [IGI]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- response to drug [ISO]
- ventricular septum morphogenesis [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin.
Wnt glycoproteins play essential roles in the development of metazoan organisms. Many Wnt proteins, such as Wnt1, activate the well-conserved canonical Wnt signaling pathway, which results in accumulation of beta-catenin in the cytosol and nucleus. Other Wnts, such as Wnt5a, activate signaling mechanisms which do not involve beta-catenin and are less well characterized. Dishevelled (Dvl) is a key component of ... [more]
Mol. Cell. Biol. Jun. 01, 2004; 24(11);4757-68 [Pubmed: 15143170]
Throughput
- Low Throughput
Ontology Terms
- abnormal protein level (MP:0008469)
Additional Notes
- expression of an Fzd1 or Fzd8 dominant negative mutant inhibits the phosphorylation of Dvl induced by expression of Wnt1
Curated By
- BioGRID