WNT1
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- Spemann organizer formation [IMP]
- T cell differentiation in thymus [IDA]
- Wnt signaling pathway [IDA, ISO]
- bone development [ISO]
- branching involved in ureteric bud morphogenesis [IGI]
- canonical Wnt signaling pathway [IDA, IGI, ISO]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [ISO]
- cell-cell signaling [IDA, TAS]
- central nervous system morphogenesis [IMP]
- cerebellum formation [IMP]
- diencephalon development [IGI]
- embryonic axis specification [IMP]
- forebrain anterior/posterior pattern specification [IGI]
- hematopoietic stem cell proliferation [IDA]
- hepatocyte differentiation [ISO]
- inner ear morphogenesis [IGI]
- metencephalon development [IMP]
- midbrain development [IMP]
- midbrain-hindbrain boundary development [IMP]
- midbrain-hindbrain boundary maturation during brain development [IMP]
- myoblast fusion [IDA, IGI]
- myotube differentiation [IGI]
- negative regulation of BMP signaling pathway [ISO]
- negative regulation of cell aging [ISO]
- negative regulation of cell differentiation [IMP]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of cell-substrate adhesion [ISO]
- negative regulation of fat cell differentiation [IDA, IMP]
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA]
- neuron fate commitment [IMP]
- neuron fate determination [IMP]
- organ morphogenesis [TAS]
- organ regeneration [ISO]
- positive regulation of Notch signaling pathway [ISO]
- positive regulation of cell proliferation [IDA, ISO]
- positive regulation of dermatome development [ISO]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of insulin-like growth factor receptor signaling pathway [ISO]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- signal transduction [TAS]
- signal transduction in response to DNA damage [ISO]
- spinal cord association neuron differentiation [IGI]
- ubiquitin-dependent SMAD protein catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FZD8
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IBA]
- T cell differentiation in thymus [IMP]
- Wnt signaling pathway [IDA]
- angiogenesis [IDA]
- canonical Wnt signaling pathway [IDA, IGI, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- non-canonical Wnt signaling pathway [IBA]
- positive regulation of JUN kinase activity [IDA]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- signal transduction [IPI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin.
Wnt glycoproteins play essential roles in the development of metazoan organisms. Many Wnt proteins, such as Wnt1, activate the well-conserved canonical Wnt signaling pathway, which results in accumulation of beta-catenin in the cytosol and nucleus. Other Wnts, such as Wnt5a, activate signaling mechanisms which do not involve beta-catenin and are less well characterized. Dishevelled (Dvl) is a key component of ... [more]
Throughput
- Low Throughput
Ontology Terms
- abnormal protein level (MP:0008469)
Additional Notes
- expression of an Fzd1 or Fzd8 dominant negative mutant inhibits the phosphorylation of Dvl induced by expression of Wnt1
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FZD8 WNT1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID